UniProt data
UniProt name: SERP1_HUMAN (Q9Y6X1)
Gene name: SERP1; Synonyms=RAMP4
Organism: Homo sapiens (Human).
Function: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity). {ECO:0000250}.
Subcellular location: Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Transmembrane domains:
- 39-59, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.
Sequence: 66 AA
CATM prediction
The sequence of SERP1_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 40 50 60 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | ASVGAWLLALFIFVVCGSAIFQIIQSI | 7.2 | -52.9° | 1.9 | 45.0 | -23.8 |
| Prolines* | ASVGPWLLALFIFVVCGSAIFQIIQSI |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 49, VAL, HA | A, 48, PHE, O | 3.48Å |
| B, 52, GLY, HA1 | A, 49, VAL, O | 3.13Å |
| A, 49, VAL, HA | B, 48, PHE, O | 3.48Å |
| A, 52, GLY, HA1 | B, 49, VAL, O | 3.13Å |