Cytochrome c oxidase assembly protein COX11, mitochondrial

UniProt data

UniProt name: COX11_HUMAN (Q9Y6N1)

Gene name: COX11

Organism: Homo sapiens (Human).

Function: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO:0000250}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:9878253}; Single-pass membrane protein {ECO:0000269|PubMed:9878253}; Intermembrane side {ECO:0000269|PubMed:9878253}.

Transmembrane domains:

  1. 96-114, 19 AA, Helical. {ECO:0000255}.

Sequence: 276 AA

10 20 30 40 50 60 MGGLWRPGWR CVPFCGWRWI HPGSPTRAAE RVEPFLRPEW SGTGGAERGL RWLGTWKRCS 70 80 90 100 110 120 LRARHPALQP PRRPKSSNPF TRAQEEERRR QNKTTLTYVA AVAVGMLGAS YAAVPLYRLY 130 140 150 160 170 180 CQTTGLGGSA VAGHASDKIE NMVPVKDRII KISFNADVHA SLQWNFRPQQ TEIYVVPGET 190 200 210 220 230 240 ALAFYRAKNP TDKPVIGIST YNIVPFEAGQ YFNKIQCFCF EEQRLNPQEE VDMPVFFYID 250 260 270 PEFAEDPRMI KVDLITLSYT FFEAKEGHKL PVPGYN

CATM prediction

The sequence of COX11_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         100       110     
  +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 KTTLTYVAAVAVGMLGASYAAVALY 6.9 -49.7° 2.8 47.0 -39.4
Model 2 KTTLTYVAAVAVGMLGASYAAVALY 6.9 -49.1° 2.9 31.9 -12.9
Prolines* KTTLTYVAAVAVGMLGASYAAVPLY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 101, ALA, HA A, 98, TYR, OH 3.17Å
B, 102, VAL, HA A, 101, ALA, O 3.03Å
B, 105, GLY, HA1 A, 102, VAL, O 2.88Å
A, 101, ALA, HA B, 98, TYR, OH 3.17Å
A, 102, VAL, HA B, 101, ALA, O 3.03Å
A, 105, GLY, HA1 B, 102, VAL, O 2.88Å