Potassium voltage-gated channel subfamily E member 2

UniProt data

UniProt name: KCNE2_HUMAN (Q9Y6J6)

Gene name: KCNE2

Organism: Homo sapiens (Human).

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). {ECO:0000250|UniProtKB:P63161, ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:11101505}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:20533308}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P63161}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO:0000250|UniProtKB:P63161}.

Transmembrane domains:

  1. 49-69, 21 AA, Helical. {ECO:0000255}.

Sequence: 123 AA

10 20 30 40 50 60 MSTLSNFTQT LEDVFRRIFI TYMDNWRQNT TAEQEALQAK VDAENFYYVI LYLMVMIGMF 70 80 90 100 110 120 SFIIVAILVS TVKSKRREHS NDPYHQYIVE DWQEKYKSQI LNLEESKATI HENIGAAGFK MSP

CATM prediction

The sequence of KCNE2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      50        60        70 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 FYYVILYLMVMIGMFSFIIVAILVSTV 7.3 -55.1° 2.4 47.7 -15.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 55, VAL, HA A, 54, MET, O 3.47Å
B, 58, GLY, HA1 A, 55, VAL, O 3.21Å
A, 55, VAL, HA B, 54, MET, O 3.47Å
A, 58, GLY, HA1 B, 55, VAL, O 3.21Å