Neuroplastin

UniProt data

UniProt name: NPTN_HUMAN (Q9Y639)

Gene name: NPTN; Synonyms=SDFR1, SDR1

Organism: Homo sapiens (Human).

Function: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Enriched at postsynaptic density. {ECO:0000250}.

Transmembrane domains:

  1. 340-360, 21 AA, Helical. {ECO:0000255}.

Sequence: 398 AA

10 20 30 40 50 60 MSGSSLPSAL ALSLLLVSGS LLPGPGAAQN AGFVKSPMSE TKLTGDAFEL YCDVVGSPTP 70 80 90 100 110 120 EIQWWYAEVN RAESFRQLWD GARKRRVTVN TAYGSNGVSV LRITRLTLED SGTYECRASN 130 140 150 160 170 180 DPKRNDLRQN PSITWIRAQA TISVLQKPRI VTSEEVIIRD SPVLPVTLQC NLTSSSHTLT 190 200 210 220 230 240 YSYWTKNGVE LSATRKNASN MEYRINKPRA EDSGEYHCVY HFVSAPKANA TIEVKAAPDI 250 260 270 280 290 300 TGHKRSENKN EGQDATMYCK SVGYPHPDWI WRKKENGMPM DIVNTSGRFF IINKENYTEL 310 320 330 340 350 360 NIVNLQITED PGEYECNATN AIGSASVVTV LRVRSHLAPL WPFLGILAEI IILVVIIVVY 370 380 390 EKRKRPDEVP DDDEPAGPMK TNSTNNHKDK NLRQRNTN

CATM prediction

The sequence of NPTN_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     340       350       360 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 LAALWAFLGILAEIIILVVIIVVYEKR 7.3 -46.0° 3.6 37.0 -13.1
Prolines* LAPLWPFLGILAEIIILVVIIVVYEKR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 342, ALA, HA A, 341, TRP, O 3.26Å
B, 345, GLY, HA1 A, 342, ALA, O 3.29Å
A, 342, ALA, HA B, 341, TRP, O 3.26Å
A, 345, GLY, HA1 B, 342, ALA, O 3.29Å