Junctional adhesion molecule A

UniProt data

UniProt name: JAM1_HUMAN (Q9Y624)

Gene name: F11R; Synonyms=JAM1, JCAM; ORFNames=UNQ264/PRO301

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}.

Subcellular location: Cell junction, tight junction {ECO:0000269|PubMed:11171323}. Cell membrane {ECO:0000269|PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269|PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000269|PubMed:11171323}.

Transmembrane domains:

  1. 239-259, 21 AA, Helical. {ECO:0000255}.

Sequence: 299 AA

10 20 30 40 50 60 MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV 70 80 90 100 110 120 EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG 130 140 150 160 170 180 EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST 190 200 210 220 230 240 RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV 250 260 270 280 290 AAVLVTLILL GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV

CATM prediction

The sequence of JAM1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      240       250       260
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 VGVIVAAVLVTLILLGILVFGIWFAYS 7.3 -51.9° 0.6 48.0 -23.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 256, GLY, HA1 A, 253, LEU, O 3.42Å
B, 257, ILE, HA A, 256, GLY, O 3.42Å
A, 256, GLY, HA1 B, 253, LEU, O 3.42Å
A, 257, ILE, HA B, 256, GLY, O 3.42Å