Beta-secretase 2

UniProt data

UniProt name: BACE2_HUMAN (Q9Y5Z0)

Gene name: BACE2; Synonyms=AEPLC, ALP56, ASP21

Organism: Homo sapiens (Human).

Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.

Subcellular location: Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.

Transmembrane domains:

  1. 474-494, 21 AA, Helical. {ECO:0000255}.

Sequence: 518 AA

10 20 30 40 50 60 MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG TPAERHADGL 70 80 90 100 110 120 ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG 130 140 150 160 170 180 TPHSYIDTYF DTERSSTYRS KGFDVTVKYT QGSWTGFVGE DLVTIPKGFN TSFLVNIATI 190 200 210 220 230 240 FESENFFLPG IKWNGILGLA YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA 250 260 270 280 290 300 GSGTNGGSLV LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA 310 320 330 340 350 360 IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET PWSYFPKISI 370 380 390 400 410 420 YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP STNALVIGAT VMEGFYVIFD 430 440 450 460 470 480 RAQKRVGFAA SPCAEIAGAA VSEISGPFST EDVASNCVPA QSLSEPILWI VSYALMSVCG 490 500 510 AILLVLIVLL LLPFRCQRRP RDPEVVNDES SLVRHRWK

CATM prediction

The sequence of BACE2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           480       490     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 VSYALMSVCGAILLVLIVLLLLAFRCQ 7.4 -53.9° 3.6 34.9 -7.6
Prolines* VSYALMSVCGAILLVLIVLLLLPFRCQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 477, SER, HA A, 476, MET, O 3.48Å
B, 480, GLY, HA1 A, 477, SER, O 3.41Å
A, 477, SER, HA B, 476, MET, O 3.48Å
A, 480, GLY, HA1 B, 477, SER, O 3.41Å