Lymphatic vessel endothelial hyaluronic acid receptor 1

UniProt data

UniProt name: LYVE1_HUMAN (Q9Y5Y7)

Gene name: LYVE1; Synonyms=CRSBP1, HAR, XLKD1; ORFNames=UNQ230/PRO263

Organism: Homo sapiens (Human).

Function: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269|PubMed:10037799}.

Subcellular location: Membrane {ECO:0000269|PubMed:10037799}; Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface.

Transmembrane domains:

  1. 239-259, 21 AA, Helical. {ECO:0000255}.

Sequence: 322 AA

10 20 30 40 50 60 MARCFSLVLL LTSIWTTRLL VQGSLRAEEL SIQVSCRIMG ITLVSKKANQ QLNFTEAKEA 70 80 90 100 110 120 CRLLGLSLAG KDQVETALKA SFETCSYGWV GDGFVVISRI SPNPKCGKNG VGVLIWKVPV 130 140 150 160 170 180 SRQFAAYCYN SSDTWTNSCI PEIITTKDPI FNTQTATQTT EFIVSDSTYS VASPYSTIPA 190 200 210 220 230 240 PTTTPPAPAS TSIPRRKKLI CVTEVFMETS TMSTETEPFV ENKAAFKNEA AGFGGVPTAL 250 260 270 280 290 300 LVLALLFFGA AAGLGFCYVK RYVKAFPFTN KNQQKEMIET KVVKEEKAND SNPNEESKKT 310 320 DKNPEESKSP SKTTVRCLEA EV

CATM prediction

The sequence of LYVE1_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      240       250       260
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 VATALLVLALLFFGAAAGLGFCYVKRY 6.5 -47.2° 4.8 56.2 -44.5
Model 2 VATALLVLALLFFGAAAGLGFCYVKRY 6.4 -52.9° 5.3 57.4 -37.5
Model 3 VATALLVLALLFFGAAAGLGFCYVKRY 6.9 -51.9° 1.3 57.3 -13.9
Model 4 VATALLVLALLFFGAAAGLGFCYVKRY 7.0 -42.6° 1.9 33.3 -6.6
Model 5 VATALLVLALLFFGAAAGLGFCYVKRY 7.1 -48.2° 5.1 39.0 -4.4
Prolines* VPTALLVLALLFFGAAAGLGFCYVKRY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 249, GLY, HA1 A, 246, LEU, O 2.92Å
B, 250, ALA, HA A, 249, GLY, O 2.43Å
B, 253, GLY, HA1 A, 250, ALA, O 3.08Å
A, 249, GLY, HA1 B, 246, LEU, O 2.92Å
A, 250, ALA, HA B, 249, GLY, O 2.43Å
A, 253, GLY, HA1 B, 250, ALA, O 3.08Å