Suppressor of tumorigenicity 14 protein

UniProt data

UniProt name: ST14_HUMAN (Q9Y5Y6)

Gene name: ST14; Synonyms=PRSS14, SNC19, TADG15

Organism: Homo sapiens (Human).

Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. {ECO:0000269|PubMed:18843291}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 56-76, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 855 AA

10 20 30 40 50 60 MGSDRARKGG GGPKDFGAGL KYNSRHEKVN GLEEGVEFLP VNNVKKVEKH GPGRWVVLAA 70 80 90 100 110 120 VLIGLLLVLL GIGFLVWHLQ YRDVRVQKVF NGYMRITNEN FVDAYENSNS TEFVSLASKV 130 140 150 160 170 180 KDALKLLYSG VPFLGPYHKE SAVTAFSEGS VIAYYWSEFS IPQHLVEEAE RVMAEERVVM 190 200 210 220 230 240 LPPRARSLKS FVVTSVVAFP TDSKTVQRTQ DNSCSFGLHA RGVELMRFTT PGFPDSPYPA 250 260 270 280 290 300 HARCQWALRG DADSVLSLTF RSFDLASCDE RGSDLVTVYN TLSPMEPHAL VQLCGTYPPS 310 320 330 340 350 360 YNLTFHSSQN VLLITLITNT ERRHPGFEAT FFQLPRMSSC GGRLRKAQGT FNSPYYPGHY 370 380 390 400 410 420 PPNIDCTWNI EVPNNQHVKV RFKFFYLLEP GVPAGTCPKD YVEINGEKYC GERSQFVVTS 430 440 450 460 470 480 NSNKITVRFH SDQSYTDTGF LAEYLSYDSS DPCPGQFTCR TGRCIRKELR CDGWADCTDH 490 500 510 520 530 540 SDELNCSCDA GHQFTCKNKF CKPLFWVCDS VNDCGDNSDE QGCSCPAQTF RCSNGKCLSK 550 560 570 580 590 600 SQQCNGKDDC GDGSDEASCP KVNVVTCTKH TYRCLNGLCL SKGNPECDGK EDCSDGSDEK 610 620 630 640 650 660 DCDCGLRSFT RQARVVGGTD ADEGEWPWQV SLHALGQGHI CGASLISPNW LVSAAHCYID 670 680 690 700 710 720 DRGFRYSDPT QWTAFLGLHD QSQRSAPGVQ ERRLKRIISH PFFNDFTFDY DIALLELEKP 730 740 750 760 770 780 AEYSSMVRPI CLPDASHVFP AGKAIWVTGW GHTQYGGTGA LILQKGEIRV INQTTCENLL 790 800 810 820 830 840 PQQITPRMMC VGFLSGGVDS CQGDSGGPLS SVEADGRIFQ AGVVSWGDGC AQRNKPGVYT 850 RLPLFRDWIK ENTGV

CATM prediction

The sequence of ST14_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         60        70        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 GRWVVLAAVLIGLLLVLLGIGFLVWHL 7.2 -54.1° 3.6 49.2 -6.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 61, VAL, HA A, 60, ALA, O 3.29Å
B, 64, GLY, HA1 A, 61, VAL, O 3.48Å
A, 61, VAL, HA B, 60, ALA, O 3.29Å
A, 64, GLY, HA1 B, 61, VAL, O 3.48Å