Protocadherin gamma-C4

UniProt data

UniProt name: PCDGL_HUMAN (Q9Y5F7)

Gene name: PCDHGC4

Organism: Homo sapiens (Human).

Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 693-713, 21 AA, Helical. {ECO:0000255}.

Sequence: 938 AA

10 20 30 40 50 60 MLRKVRSWTE IWRWATLLFL FYHLGYVCGQ IRYPVPEESQ EGTFVGNVAQ DFLLDTDSLS 70 80 90 100 110 120 ARRLQVAGEV NQRHFRVDLD SGALLIKNPI DREALCGLSA SCIVPLEFVT EGPLEMYRAE 130 140 150 160 170 180 VEIVDVNDHA PRFPRQQLDL EIGEAAPPGQ RFPLEKAQDA DVGSNSISSY RLSSNEHFAL 190 200 210 220 230 240 DVKKRSDGSL VPELLLEKPL DREKQSDYRL VLTAVDGGNP PRSGTAELRV SVLDVNDNAP 250 260 270 280 290 300 AFQQSSYRIS VLESAPAGMV LIQLNASDPD LGPSGNVTFY FSGHTPDRVR NLFSLHPTTG 310 320 330 340 350 360 KLTLLGPLDF ESENYYEFDV RARDGGSPAM EQHCSLRVDL LDVNDNAPYI TVTSELGTLP 370 380 390 400 410 420 ESAEPGTVVA LISVQDPDSG SNGDVSLRIP DHLPFALKSA FRNQFSLVTA GPLDREAKSS 430 440 450 460 470 480 YDIMVTASDA GNPPLSTHRT IFLNISDVND NPPSFFQRSH EVFVPENNRP GDLLCSLAAS 490 500 510 520 530 540 DPDSGLNALI SYSLLEPRNR DVSASSFISL NPQTGAVHAT RSFDYEQTQT LQFEVQARDR 550 560 570 580 590 600 GNPPLSSTVT VRLFVLDLND NAPAVLRPRA RPGSLCPQAL PPSVGAGHLI TKVTAVDLDS 610 620 630 640 650 660 GYNAWVSYQL LEAPDPSLFA VSRYAGEVRT AVPIPADLPP QKLVIVVKDS GSPPLSTSVT 670 680 690 700 710 720 LLVSLEEDTH PVVPDLRESS APREGESRLT LYLAVSLVAI CFVSFGSFVA LLSKCLRGAA 730 740 750 760 770 780 CGVTCFPAGT CACLTRSRRR EGLPPSNGIL RIQLGSDDPI KFVDVGGHSH GCTPLASAPT 790 800 810 820 830 840 RSDSFMMVKS PSAPMAGEPV RPSCPPSDLL YGLEQAPPNT DWRFSQAQRP GTSGSQNGDD 850 860 870 880 890 900 TGTWPNNQFD TEMLQAMILA SASEAADGSS TLGGGAGTMG LSARYGPQFT LQHVPDYRQN 910 920 930 VYIPGSNATL TNAAGKRDGK APAGGNGNKK KSGKKEKK

CATM prediction

The sequence of PCDGL_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  690       700       710    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 TLYLAVSLVAICFVSFGSFVALLSKCL 6.9 -49.0° 1.8 44.9 -25.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 703, VAL, HA A, 702, PHE, O 3.18Å
B, 706, GLY, HA1 A, 703, VAL, O 2.85Å
B, 707, SER, HA A, 706, GLY, O 3.34Å
A, 703, VAL, HA B, 702, PHE, O 3.18Å
A, 706, GLY, HA1 B, 703, VAL, O 2.85Å
A, 707, SER, HA B, 706, GLY, O 3.34Å