Low-density lipoprotein receptor-related protein 12

UniProt data

UniProt name: LRP12_HUMAN (Q9Y561)

Gene name: LRP12; Synonyms=ST7

Organism: Homo sapiens (Human).

Function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. {ECO:0000269|PubMed:12809483}.

Subcellular location: Membrane {ECO:0000269|PubMed:12809483}; Single-pass type I membrane protein {ECO:0000269|PubMed:12809483}. Membrane, coated pit {ECO:0000269|PubMed:12809483}.

Transmembrane domains:

  1. 493-513, 21 AA, Helical. {ECO:0000255}.

Sequence: 859 AA

10 20 30 40 50 60 MACRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET PEQIRAPSGI 70 80 90 100 110 120 ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS RRCNLDWLTI ETYKNIESYR 130 140 150 160 170 180 ACGSTIPPPY ISSQDHIWIR FHSDDNISRK GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP 190 200 210 220 230 240 EAWKCNNMDE CGDSSDEEIC AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD 250 260 270 280 290 300 GNIDCLDLGD EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR 310 320 330 340 350 360 FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI RVHFCADKVN 370 380 390 400 410 420 AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH CPNGRDETNC TMCQKEEFPC 430 440 450 460 470 480 SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF CQPGNFHCKN NRCVFESWVC DSQDDCGDGS 490 500 510 520 530 540 DEENCPVIVP TRVITAAVIG SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL 550 560 570 580 590 600 LRREAPPSYG QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS 610 620 630 640 650 660 NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV ESDDTDTENE 670 680 690 700 710 720 RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST RGGHADNGRD VTSVEPPSVS 730 740 750 760 770 780 PARHQLTSAL SRMTQGLRWV RFTLGRSSSL SQNQSPLRQL DNGVSGREDD DDVEMLIPIS 790 800 810 820 830 840 DGSSDFDVND CSRPLLDLAS DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT 850 CLEVTLKNET SDDEALLLC

CATM prediction

The sequence of LRP12_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  490       500       510    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ATRVITAAVIGSLICGLLLVIALGCTC 6.7 -49.6° 2.8 47.0 -20.1
Prolines* PTRVITAAVIGSLICGLLLVIALGCTC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 497, ALA, HA A, 496, ALA, O 2.77Å
B, 500, GLY, HA1 A, 497, ALA, O 2.70Å
A, 497, ALA, HA B, 496, ALA, O 2.77Å
A, 500, GLY, HA1 B, 497, ALA, O 2.70Å