Neurexin-3

UniProt data

UniProt name: NRX3A_HUMAN (Q9Y4C0)

Gene name: NRXN3; Synonyms=C14orf60, KIAA0743

Organism: Homo sapiens (Human).

Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1569-1589, 21 AA, Helical. {ECO:0000255}.

Sequence: 1643 AA

10 20 30 40 50 60 MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS 70 80 90 100 110 120 TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR 130 140 150 160 170 180 TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK 190 200 210 220 230 240 YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ 250 260 270 280 290 300 DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG 310 320 330 340 350 360 KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG 370 380 390 400 410 420 ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS 430 440 450 460 470 480 RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP 490 500 510 520 530 540 NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG 550 560 570 580 590 600 EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT 610 620 630 640 650 660 AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD 670 680 690 700 710 720 GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG 730 740 750 760 770 780 LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR 790 800 810 820 830 840 VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF 850 860 870 880 890 900 NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK 910 920 930 940 950 960 TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT 970 980 990 1000 1010 1020 RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA 1030 1040 1050 1060 1070 1080 SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY 1090 1100 1110 1120 1130 1140 SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL 1150 1160 1170 1180 1190 1200 GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN 1210 1220 1230 1240 1250 1260 EHYPTGRQLT IFNTQAQIAI GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN NPNIKINGSV 1270 1280 1290 1300 1310 1320 RLVGEVPSIL GTTQTTSMPP EMSTTVMETT TTMATTTTRK NRSTASIQPT SDDLVSSAEC 1330 1340 1350 1360 1370 1380 SSDDEDFVEC EPSTTGGELV IPLLVEDPLA TPPIATRAPS ITLPPTFRPL LTIIETTKDS 1390 1400 1410 1420 1430 1440 LSMTSEAGLP CLSDQGSDGC DDDGLVISGY GSGETFDSNL PPTDDEDFYT TFSLVTDKSL 1450 1460 1470 1480 1490 1500 STSIFEGGYK AHAPKWESKD FRPNKVSETS RTTTTSLSPE LIRFTASSSS GMVPKLPAGK 1510 1520 1530 1540 1550 1560 MNNRDLKPQP DIVLLPLPTA YELDSTKLKS PLITSPMFRN VPTANPTEPG IRRVPGASEV 1570 1580 1590 1600 1610 1620 IRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY QVDETRNYIS NSAQSNGTLM 1630 1640 KEKQQSSKSG HKKQKNKDRE YYV

CATM prediction

The sequence of NRX3A_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      1570      1580      159
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 STTGMVVGIVAAAALCILILLYAMYKY 6.6 -40.0° 4.5 44.0 -29.8
Model 2 STTGMVVGIVAAAALCILILLYAMYKY 6.4 -54.9° 4.9 53.1 -18.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1570, MET, HA A, 1569, GLY, O 2.47Å
B, 1573, GLY, HA1 A, 1570, MET, O 2.86Å
A, 1570, MET, HA B, 1569, GLY, O 2.47Å
A, 1573, GLY, HA1 B, 1570, MET, O 2.86Å