Zonadhesin

UniProt data

UniProt name: ZAN_HUMAN (Q9Y493)

Gene name: ZAN

Organism: Homo sapiens (Human).

Function: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head. {ECO:0000250}.

Transmembrane domains:

  1. 2758-2778, 21 AA, Helical. {ECO:0000255}.

Sequence: 2812 AA

10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 2610 2620 2630 2640 QDPREQEELR CQVLSGHGVS SRYHISELYD TLPSILCQPG RPRGLRGPLR GRLRQHPRLC 2650 2660 2670 2680 2690 2700 LQWHPEPPLA DCGCTSNGIY YQLGSSFLTE DCSQRCTCAS SRILLCEPFS CRAGEVCTLG 2710 2720 2730 2740 2750 2760 NHTQGCFPES PCLQNPCQND GQCREQGATF TCECEVGYGG GLCMEPRDAP PPRKPASNLV 2770 2780 2790 2800 2810 AVLLGLLVPV VVVLLAVTRE CIYRTRRKRE KTQEGDRLAR LVDTDTVLDC AC

CATM prediction

The sequence of ZAN_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       2760      2770      27
+    |    +    |    +    | 
(Å) (°) (Å) (°)  
AASNLVAVLLGLLVAVVVVLLAVTREC 7.2 -43.0° 3.4 50.0 -10.4
PASNLVAVLLGLLVPVVVVLLAVTREC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 2762, VAL, HA A, 2761, ALA, O 3.07Å
B, 2765, GLY, HA1 A, 2762, VAL, O 3.30Å
A, 2762, VAL, HA B, 2761, ALA, O 3.07Å
A, 2765, GLY, HA1 B, 2762, VAL, O 3.30Å