Transmembrane emp24 domain-containing protein 3

UniProt data

UniProt name: TMED3_HUMAN (Q9Y3Q3)

Gene name: TMED3; Synonyms=C15orf22; ORFNames=UNQ5357/PRO1078

Organism: Homo sapiens (Human).

Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. {ECO:0000269|PubMed:10852829}.

Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q6AY25}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000305|PubMed:16940185}; Single-pass type I membrane protein {ECO:0000255}. Note=Probably cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:10852829}.

Transmembrane domains:

  1. 181-201, 21 AA, Helical. {ECO:0000255}.

Sequence: 217 AA

10 20 30 40 50 60 MGSTVPRSAS VLLLLLLLRR AEQPCGAELT FELPDNAKQC FHEEVEQGVK FSLDYQVITG 70 80 90 100 110 120 GHYDVDCYVE DPQGNTIYRE TKKQYDSFTY RAEVKGVYQF CFSNEFSTFS HKTVYFDFQV 130 140 150 160 170 180 GDEPPILPDM GNRVTALTQM ESACVTIHEA LKTVIDSQTH YRLREAQDRA RAEDLNSRVS 190 200 210 YWSVGETIAL FVVSFSQVLL LKSFFTEKRP ISRAVHS

CATM prediction

The sequence of TMED3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    180       190       200  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 RVSYWSVGETIALFVVSFSQVLLLKSF 7.2 -51.9° 0.6 48.0 -10.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 185, GLY, HA1 A, 182, TRP, O 3.29Å
B, 186, GLU, HA A, 185, GLY, O 3.36Å
B, 185, GLY, HA2 A, 186, GLU, OE2 3.16Å
A, 185, GLY, HA1 B, 182, TRP, O 3.29Å
A, 186, GLU, HA B, 185, GLY, O 3.36Å
A, 185, GLY, HA2 B, 186, GLU, OE2 3.16Å