Signaling threshold-regulating transmembrane adapter 1

UniProt data

UniProt name: SIT1_HUMAN (Q9Y3P8)

Gene name: SIT1; Synonyms=SIT

Organism: Homo sapiens (Human).

Function: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269|PubMed:10209036}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:10209036}; Single-pass type I membrane protein {ECO:0000269|PubMed:10209036}.

Transmembrane domains:

  1. 41-61, 21 AA, Helical. {ECO:0000255}.

Sequence: 196 AA

10 20 30 40 50 60 MNQADPRLRA VCLWTLTSAA MSRGDNCTDL LALGIPSITQ AWGLWVLLGA VTLLFLISLA 70 80 90 100 110 120 AHLSQWTRGR SRSHPGQGRS GESVEEVPLY GNLHYLQTGR LSQDPEPDQQ DPTLGGPARA 130 140 150 160 170 180 AEEVMCYTSL QLRPPQGRIP GPGTPVKYSE VVLDSEPKSQ ASGPEPELYA SVCAQTRRAR 190 ASFPDQAYAN SQPAAS

CATM prediction

The sequence of SIT1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    40        50        60   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ITQAWGLWVLLGAVTLLFLISLAAHLS 6.8 -55.0° 2.4 47.5 -1.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 46, VAL, HA A, 45, TRP, O 2.97Å
B, 49, GLY, HA1 A, 46, VAL, O 2.68Å
A, 46, VAL, HA B, 45, TRP, O 2.97Å
A, 49, GLY, HA1 B, 46, VAL, O 2.68Å