Mitochondrial fission 1 protein

UniProt data

UniProt name: FIS1_HUMAN (Q9Y3D6)

Gene name: FIS1; Synonyms=TTC11; ORFNames=CGI-135

Organism: Homo sapiens (Human).

Function: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241}.

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 123-143, 21 AA, Helical. {ECO:0000255}.

Sequence: 152 AA

10 20 30 40 50 60 MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE 70 80 90 100 110 120 LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK 130 140 150 DGLVGMAIVG GMALGVAGLA GLIGLAVSKS KS

CATM prediction

The sequence of FIS1_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  120       130       140    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 KDGLVGMAIVGGMALGVAGLAGLIGLA 6.9 -50.0° 2.8 47.1 -24.2
Model 2 KDGLVGMAIVGGMALGVAGLAGLIGLA 7.3 -34.0° 2.7 38.2 -18.4
Model 3 KDGLVGMAIVGGMALGVAGLAGLIGLA 7.1 +52.0° 1.8 1.1 -14.0
Model 4 KDGLVGMAIVGGMALGVAGLAGLIGLA 7.0 -43.0° 5.5 34.0 -12.6
Model 5 KDGLVGMAIVGGMALGVAGLAGLIGLA 7.0 -37.0° 0.0 37.0 -12.5
Model 6 KDGLVGMAIVGGMALGVAGLAGLIGLA 7.1 -53.2° 3.1 34.1 -11.2
Model 7 KDGLVGMAIVGGMALGVAGLAGLIGLA 7.1 -53.9° 4.8 41.1 -5.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 128, ILE, HA A, 127, ALA, O 2.96Å
B, 131, GLY, HA1 A, 128, ILE, O 2.90Å
A, 128, ILE, HA B, 127, ALA, O 2.96Å
A, 131, GLY, HA1 B, 128, ILE, O 2.90Å