Sialic acid-binding Ig-like lectin 9

UniProt data

UniProt name: SIGL9_HUMAN (Q9Y336)

Gene name: SIGLEC9; ORFNames=UNQ668/PRO1302

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 349-369, 21 AA, Helical. {ECO:0000255}.

Sequence: 463 AA

10 20 30 40 50 60 MLLLLLPLLW GRERAEGQTS KLLTMQSSVT VQEGLCVHVP CSFSYPSHGW IYPGPVVHGY 70 80 90 100 110 120 WFREGANTDQ DAPVATNNPA RAVWEETRDR FHLLGDPHTK NCTLSIRDAR RSDAGRYFFR 130 140 150 160 170 180 MEKGSIKWNY KHHRLSVNVT ALTHRPNILI PGTLESGCPQ NLTCSVPWAC EQGTPPMISW 190 200 210 220 230 240 IGTSVSPLDP STTRSSVLTL IPQPQDHGTS LTCQVTFPGA SVTTNKTVHL NVSYPPQNLT 250 260 270 280 290 300 MTVFQGDGTV STVLGNGSSL SLPEGQSLRL VCAVDAVDSN PPARLSLSWR GLTLCPSQPS 310 320 330 340 350 360 NPGVLELPWV HLRDAAEFTC RAQNPLGSQQ VYLNVSLQSK ATSGVTQGVV GGAGATALVF 370 380 390 400 410 420 LSFCVIFVVV RSCRKKSARP AAGVGDTGIE DANAVRGSAS QGPLTEPWAE DSPPDQPPPA 430 440 450 460 SARSSVGEGE LQYASLSFQM VKPWDSRGQE ATDTEYSEIK IHR

CATM prediction

The sequence of SIGL9_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      350       360       370
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 TQGVVGGAGATALVFLSFCVIFVVVRS 7.3 -47.2° 2.3 45.0 -22.2
Model 2 TQGVVGGAGATALVFLSFCVIFVVVRS 7.1 -43.0° 0.0 34.0 -15.9
Model 3 TQGVVGGAGATALVFLSFCVIFVVVRS 6.7 -55.0° 5.0 52.7 -12.4
Model 4 TQGVVGGAGATALVFLSFCVIFVVVRS 6.7 -46.0° 3.6 37.0 -7.8
Model 5 TQGVVGGAGATALVFLSFCVIFVVVRS 7.1 +52.0° 1.8 1.0 -6.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 352, GLY, HA1 A, 349, VAL, O 3.28Å
B, 353, ALA, HA A, 356, THR, OG1 2.41Å
A, 352, GLY, HA1 B, 349, VAL, O 3.28Å
A, 353, ALA, HA B, 356, THR, OG1 2.41Å