Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

UniProt data

UniProt name: COA3_HUMAN (Q9Y2R0)

Gene name: COA3; Synonyms=CCDC56, MITRAC12; ORFNames=HSPC009

Organism: Homo sapiens (Human).

Function: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. {ECO:0000269|PubMed:23260140}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23260140}; Single-pass membrane protein {ECO:0000269|PubMed:23260140}.

Transmembrane domains:

  1. 58-78, 21 AA, Helical. {ECO:0000255}.

Sequence: 106 AA

10 20 30 40 50 60 MASSGAGDPL DSKRGEAPFA QRIDPTREKL TPEQLHSMRQ AELAQWQKVL PRRRTRNIVT 70 80 90 100 GLGIGALVLA IYGYTFYSIS QERFLDELED EAKAARARAL ARASGS

CATM prediction

The sequence of COA3_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       60        70        80
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TRNIVTGLGIGALVLAIYGYTFYSISQ 7.0 -51.9° 1.3 57.1 -21.9
Model 2 TRNIVTGLGIGALVLAIYGYTFYSISQ 7.1 -36.0° 2.4 59.0 -21.4
Model 3 TRNIVTGLGIGALVLAIYGYTFYSISQ 6.4 -54.8° 2.4 47.8 -14.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 61, GLY, HA1 A, 58, ILE, O 3.11Å
B, 62, LEU, HA A, 61, GLY, O 3.41Å
A, 61, GLY, HA1 B, 58, ILE, O 3.11Å
A, 62, LEU, HA B, 61, GLY, O 3.41Å