UniProt data
UniProt name: ITM2B_HUMAN (Q9Y287)
Gene name: ITM2B; Synonyms=BRI, BRI2
Organism: Homo sapiens (Human).
Function: Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.
Subcellular location: BRI2C, soluble form: Secreted {ECO:0000269|PubMed:17965014}.
Transmembrane domains:
- 55-75, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 266 AA
10 20 30 40 50 60
MVKVTFNSAL AQKEAKKDEP KSGEEALIIP PDAVAVDCKD PDDVVPVGQR RAWCWCMCFG
70 80 90 100 110 120
LAFMLAGVIL GGAYLYKYFA LQPDDVYYCG IKYIKDDVIL NEPSADAPAA LYQTIEENIK
130 140 150 160 170 180
IFEEEEVEFI SVPVPEFADS DPANIVHDFN KKLTAYLDLN LDKCYVIPLN TSIVMPPRNL
190 200 210 220 230 240
LELLINIKAG TYLPQSYLIH EHMVITDRIE NIDHLGFFIY RLCHDKETYK LQRRETIKGI
250 260
QKREASNCFA IRHFENKFAV ETLICS
CATM prediction
The sequence of ITM2B_HUMAN returned 5 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 60 70 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | AWCWCMCFGLAFMLAGVILGGAYLYKY | 6.9 | -50.0° | 2.9 | 47.0 | -24.6 |
| Model 2 | AWCWCMCFGLAFMLAGVILGGAYLYKY | 7.1 | -50.0° | 2.8 | 47.1 | -21.6 |
| Model 3 | AWCWCMCFGLAFMLAGVILGGAYLYKY | 7.0 | -31.1° | 4.1 | 50.7 | -19.5 |
| Model 4 | AWCWCMCFGLAFMLAGVILGGAYLYKY | 7.1 | -54.0° | 3.6 | 48.6 | -11.7 |
| Model 5 | AWCWCMCFGLAFMLAGVILGGAYLYKY | 7.0 | -55.1° | 1.5 | 45.1 | -5.3 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 64, MET, HA | A, 63, PHE, O | 2.96Å |
| B, 67, GLY, HA1 | A, 64, MET, O | 2.88Å |
| A, 64, MET, HA | B, 63, PHE, O | 2.96Å |
| A, 67, GLY, HA1 | B, 64, MET, O | 2.88Å |
