Sialic acid-binding Ig-like lectin 7

UniProt data

UniProt name: SIGL7_HUMAN (Q9Y286)

Gene name: SIGLEC7; Synonyms=AIRM1

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 354-376, 23 AA, Helical. {ECO:0000255}.

Sequence: 467 AA

10 20 30 40 50 60 MLLLLLLPLL WGRERVEGQK SNRKDYSLTM QSSVTVQEGM CVHVRCSFSY PVDSQTDSDP 70 80 90 100 110 120 VHGYWFRAGN DISWKAPVAT NNPAWAVQEE TRDRFHLLGD PQTKNCTLSI RDARMSDAGR 130 140 150 160 170 180 YFFRMEKGNI KWNYKYDQLS VNVTALTHRP NILIPGTLES GCFQNLTCSV PWACEQGTPP 190 200 210 220 230 240 MISWMGTSVS PLHPSTTRSS VLTLIPQPQH HGTSLTCQVT LPGAGVTTNR TIQLNVSYPP 250 260 270 280 290 300 QNLTVTVFQG EGTASTALGN SSSLSVLEGQ SLRLVCAVDS NPPARLSWTW RSLTLYPSQP 310 320 330 340 350 360 SNPLVLELQV HLGDEGEFTC RAQNSLGSQH VSLNLSLQQE YTGKMRPVSG VLLGAVGGAG 370 380 390 400 410 420 ATALVFLSFC VIFIVVRSCR KKSARPAADV GDIGMKDANT IRGSASQGNL TESWADDNPR 430 440 450 460 HHGLAAHSSG EEREIQYAPL SFHKGEPQDL SGQEATNNEY SEIKIPK

CATM prediction

The sequence of SIGL7_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           360       370       
    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 VLLGAVGGAGATALVFLSFCVIFIVVRSC 6.6 -45.1° 4.0 39.1 -33.4
Model 2 VLLGAVGGAGATALVFLSFCVIFIVVRSC 6.6 -54.7° 5.5 40.3 -20.3
Model 3 VLLGAVGGAGATALVFLSFCVIFIVVRSC 6.8 -48.0° 1.0 37.0 -17.3
Model 4 VLLGAVGGAGATALVFLSFCVIFIVVRSC 7.1 +52.0° 1.8 1.0 -11.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 355, ALA, HA A, 354, GLY, O 2.55Å
B, 358, GLY, HA1 A, 355, ALA, O 2.73Å
B, 359, ALA, HA A, 362, THR, OG1 2.60Å
A, 355, ALA, HA B, 354, GLY, O 2.55Å
A, 358, GLY, HA1 B, 355, ALA, O 2.73Å
A, 359, ALA, HA B, 362, THR, OG1 2.60Å