Mitochondrial chaperone BCS1

UniProt data

UniProt name: BCS1_HUMAN (Q9Y276)

Gene name: BCS1L; Synonyms=BCS1

Organism: Homo sapiens (Human).

Function: Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. {ECO:0000269|PubMed:18628306}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:9878253}; Single- pass membrane protein {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:9878253}.

Transmembrane domains:

  1. 16-32, 17 AA, Helical. {ECO:0000255}.

Sequence: 419 AA

10 20 30 40 50 60 MPLSDFILAL KDNPYFGAGF GLVGVGTALA LARKGVQLGL VAFRRHYMIT LEVPARDRSY 70 80 90 100 110 120 AWLLSWLTRH STRTQHLSVE TSYLQHESGR ISTKFEFVPS PGNHFIWYRG KWIRVERSRE 130 140 150 160 170 180 MQMIDLQTGT PWESVTFTAL GTDRKVFFNI LEEARELALQ QEEGKTVMYT AVGSEWRPFG 190 200 210 220 230 240 YPRRRRPLNS VVLQQGLADR IVRDVQEFID NPKWYTDRGI PYRRGYLLYG PPGCGKSSFI 250 260 270 280 290 300 TALAGELEHS ICLLSLTDSS LSDDRLNHLL SVAPQQSLVL LEDVDAAFLS RDLAVENPVK 310 320 330 340 350 360 YQGLGRLTFS GLLNALDGVA STEARIVFMT TNHVDRLDPA LIRPGRVDLK EYVGYCSHWQ 370 380 390 400 410 LTQMFQRFYP GQAPSLAENF AEHVLRATNQ ISPAQVQGYF MLYKNDPVGA IHNAESLRR

CATM prediction

The sequence of BCS1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         20        30    
  +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 NAYFGAGFGLVGVGTALALARKG 7.3 -37.8° 3.2 35.1 -20.2
Model 2 NAYFGAGFGLVGVGTALALARKG 6.9 -23.0° 4.2 54.0 -11.3
Model 3 NAYFGAGFGLVGVGTALALARKG 7.3 -38.0° 3.1 35.0 -2.8
Prolines* NPYFGAGFGLVGVGTALALARKG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 21, GLY, HA2 A, 20, PHE, O 3.39Å
B, 24, GLY, HA1 A, 21, GLY, O 3.30Å
A, 21, GLY, HA2 B, 20, PHE, O 3.39Å
A, 24, GLY, HA1 B, 21, GLY, O 3.30Å