Protein jagged-2

UniProt data

UniProt name: JAG2_HUMAN (Q9Y219)

Gene name: JAG2

Organism: Homo sapiens (Human).

Function: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1081-1101, 21 AA, Helical. {ECO:0000255}.

Sequence: 1238 AA

10 20 30 40 50 60 MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC DGDGRTTRAG 70 80 90 100 110 120 GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG NSFYLPPAGA AGDRARARAR 130 140 150 160 170 180 AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD WDNDTTPNEE LLIERVSHAG MINPEDRWKS 190 200 210 220 230 240 LHFSGHVAHL ELQIRVRCDE NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC 250 260 270 280 290 300 KEAVCKQGCN LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG 310 320 330 340 350 360 GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA CTSNPCANGG 370 380 390 400 410 420 SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC VDQVDGFECI CPEQWVGATC 430 440 450 460 470 480 QLDANECEGK PCLNAFSCKN LIGGYYCDCI PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN 490 500 510 520 530 540 GYQCVCPRGF GGRHCELERD ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC 550 560 570 580 590 600 EPSPCRNGAR CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT 610 620 630 640 650 660 AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT CIDEVDAFRC 670 680 690 700 710 720 FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC DDGWKGKTCH SREFQCDAYT 730 740 750 760 770 780 CSNGGTCYDS GDTFRCACPP GWKGSTCAVA KNSSCLPNPC VNGGTCVGSG ASFSCICRDG 790 800 810 820 830 840 WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA 850 860 870 880 890 900 TCVDEINGYR CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD 910 920 930 940 950 960 CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG AEEPPSTPCL 970 980 990 1000 1010 1020 PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA TRAVARDRLL VLLCDRASSG 1030 1040 1050 1060 1070 1080 ASAVEVAVSF SPARDLPDSS LIQGAAHAIV AAITQRGNSS LLLAVTEVKV ETVVTGGSST 1090 1100 1110 1120 1130 1140 GLLVPVLCGA FSVLWLACVV LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER 1150 1160 1170 1180 1190 1200 PGGHKDVLYQ CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK 1210 1220 1230 FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE

CATM prediction

The sequence of JAG2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    1080      1090      1100 
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 SSTGLLVAVLCGAFSVLWLACVVLCVW 7.1 -50.7° 3.3 48.1 -19.5
Prolines* SSTGLLVPVLCGAFSVLWLACVVLCVW          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1086, VAL, HA A, 1085, ALA, O 3.01Å
B, 1089, GLY, HA1 A, 1086, VAL, O 3.12Å
A, 1086, VAL, HA B, 1085, ALA, O 3.01Å
A, 1089, GLY, HA1 B, 1086, VAL, O 3.12Å