Lysosome-associated membrane glycoprotein 3

UniProt data

UniProt name: LAMP3_HUMAN (Q9UQV4)

Gene name: LAMP3; Synonyms=DCLAMP, TSC403

Organism: Homo sapiens (Human).

Function: May play a role in dendritic cell function and in adaptive immunity. {ECO:0000269|PubMed:9768752}.

Subcellular location: Lysosome membrane {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9768752}; Single- pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9768752}; Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). {ECO:0000269|PubMed:9768752}.

Transmembrane domains:

  1. 382-402, 21 AA, Helical. {ECO:0000255|PROSITE- ProRule:PRU00740}.

Sequence: 416 AA

10 20 30 40 50 60 MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP 70 80 90 100 110 120 HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV 130 140 150 160 170 180 TEVTVGPSLA PYSLPPTITP PAHTTGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST 190 200 210 220 230 240 TGQKPVQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA 250 260 270 280 290 300 EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 310 320 330 340 350 360 YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL 370 380 390 400 410 QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI

CATM prediction

The sequence of LAMP3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   380       390       400   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 DYTIVLAVIGAIVVGLCLMGMGVYKIR 6.9 -46.1° 2.7 47.0 -22.9
Model 2 DYTIVLAVIGAIVVGLCLMGMGVYKIR 7.0 -55.0° 1.5 44.9 -11.8
Prolines* DYTIVLPVIGAIVVGLCLMGMGVYKIR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 390, ILE, HA A, 389, ALA, O 2.91Å
B, 393, GLY, HA1 A, 390, ILE, O 2.87Å
B, 394, LEU, HA A, 393, GLY, O 3.48Å
A, 390, ILE, HA B, 389, ALA, O 2.91Å
A, 393, GLY, HA1 B, 390, ILE, O 2.87Å
A, 394, LEU, HA B, 393, GLY, O 3.48Å