N-acetylated-alpha-linked acidic dipeptidase-like protein

UniProt data

UniProt name: NALDL_HUMAN (Q9UQQ1)

Gene name: NAALADL1; Synonyms=NAALADASEL, NAALADL

Organism: Homo sapiens (Human).

Function: NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity). {ECO:0000250}.

Subcellular location: Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane.

Transmembrane domains:

  1. 7-28, 22 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 740 AA

10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 310 320 330 340 350 360 TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD 370 380 390 400 410 420 RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL 430 440 450 460 470 480 IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD 490 500 510 520 530 540 LSIYDNWIRY FNRSSPVYGL VPSLGSLGAG SDYAPFVHFL GISSMDIAYT YDRSKTSARI 550 560 570 580 590 600 YPTYHTAFDT FDYVDKFLDP GFSSHQAVAR TAGSVILRLS DSFFLPLKVS DYSETLRSFL 610 620 630 640 650 660 QAAQQDLGAL LEQHSISLGP LVTAVEKFEA EAAALGQRIS TLQKGSPDPL QVRMLNDQLM 670 680 690 700 710 720 LLERTFLNPR AFPEERYYSH VLWAPRTGSV VTFPGLSNAC SRARDTASGS EAWAEVQRQL 730 SIVVTALEGA AATLRPVADL

CATM prediction

The sequence of NALDL_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20        30
 +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TKVLGLGLGAAALLGLGIILGHFAIAKK 7.3 -48.0° 0.7 54.0 -21.2
Model 2 TKVLGLGLGAAALLGLGIILGHFAIAKK 7.3 -55.2° 4.2 37.8 -11.8
Model 3 TKVLGLGLGAAALLGLGIILGHFAIAKK 6.9 -55.0° 1.5 45.0 -8.2
Model 4 TKVLGLGLGAAALLGLGIILGHFAIAKK 7.3 -43.0° 2.4 44.0 -7.5
Model 5 TKVLGLGLGAAALLGLGIILGHFAIAKK 7.3 -30.0° 4.7 39.0 -4.4
Model 6 TKVLGLGLGAAALLGLGIILGHFAIAKK 7.3 -54.2° 3.6 48.9 -1.9
Prolines* TKVLGLGLGAAALLGLGIILGHFAIPKK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 20, GLY, HA1 A, 17, LEU, O 3.28Å
B, 21, ILE, HA A, 20, GLY, O 3.48Å
A, 20, GLY, HA1 B, 17, LEU, O 3.28Å
A, 21, ILE, HA B, 20, GLY, O 3.48Å