UniProt data

UniProt name: SYCY1_HUMAN (Q9UQF0)

Gene name: ERVW-1; Synonyms=ERVWE1

Organism: Homo sapiens (Human).

Function: Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

Subcellular location: Syncytin-1: Virion {ECO:0000250}.

Transmembrane domains:

1. 444-464, 21 AA, Helical. {ECO:0000255}.

Sequence: 538 AA

CATM prediction

The sequence of SYCY1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.