Calcium-activated chloride channel regulator 2

UniProt data

UniProt name: CLCA2_HUMAN (Q9UQC9)

Gene name: CLCA2; Synonyms=CACC3

Organism: Homo sapiens (Human).

Function: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.

Subcellular location: Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.

Transmembrane domains:

  1. 902-922, 21 AA, Helical. {ECO:0000255}.

Sequence: 943 AA

10 20 30 40 50 60 MTQRSIAGPI CNLKFVTLLV ALSSELPFLG AGVQLQDNGY NGLLIAINPQ VPENQNLISN 70 80 90 100 110 120 IKEMITEASF YLFNATKRRV FFRNIKILIP ATWKANNNSK IKQESYEKAN VIVTDWYGAH 130 140 150 160 170 180 GDDPYTLQYR GCGKEGKYIH FTPNFLLNDN LTAGYGSRGR VFVHEWAHLR WGVFDEYNND 190 200 210 220 230 240 KPFYINGQNQ IKVTRCSSDI TGIFVCEKGP CPQENCIISK LFKEGCTFIY NSTQNATASI 250 260 270 280 290 300 MFMQSLSSVV EFCNASTHNQ EAPNLQNQMC SLRSAWDVIT DSADFHHSFP MNGTELPPPP 310 320 330 340 350 360 TFSLVQAGDK VVCLVLDVSS KMAEADRLLQ LQQAAEFYLM QIVEIHTFVG IASFDSKGEI 370 380 390 400 410 420 RAQLHQINSN DDRKLLVSYL PTTVSAKTDI SICSGLKKGF EVVEKLNGKA YGSVMILVTS 430 440 450 460 470 480 GDDKLLGNCL PTVLSSGSTI HSIALGSSAA PNLEELSRLT GGLKFFVPDI SNSNSMIDAF 490 500 510 520 530 540 SRISSGTGDI FQQHIQLEST GENVKPHHQL KNTVTVDNTV GNDTMFLVTW QASGPPEIIL 550 560 570 580 590 600 FDPDGRKYYT NNFITNLTFR TASLWIPGTA KPGHWTYTLN NTHHSLQALK VTVTSRASNS 610 620 630 640 650 660 AVPPATVEAF VERDSLHFPH PVMIYANVKQ GFYPILNATV TATVEPETGD PVTLRLLDDG 670 680 690 700 710 720 AGADVIKNDG IYSRYFFSFA ANGRYSLKVH VNHSPSISTP AHSIPGSHAM YVPGYTANGN 730 740 750 760 770 780 IQMNAPRKSV GRNEEERKWG FSRVSSGGSF SVLGVPAGPH PDVFPPCKII DLEAVKVEEE 790 800 810 820 830 840 LTLSWTAPGE DFDQGQATSY EIRMSKSLQN IQDDFNNAIL VNTSKRNPQQ AGIREIFTFS 850 860 870 880 890 900 PQISTNGPEH QPNGETHESH RIYVAIRAMD RNSLQSAVSN IAQAPLFIPP NSDPVPARDY 910 920 930 940 LILKGVLTAM GLIGIICLII VVTHHTLSRK KRADKKENGT KLL

CATM prediction

The sequence of CLCA2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   900       910       920   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 DYLILKGVLTAMGLIGIICLIIVVTHH 7.2 -49.0° 1.8 45.2 -21.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 905, GLY, HA1 A, 902, ILE, O 3.02Å
B, 906, VAL, HA A, 905, GLY, O 3.35Å
A, 905, GLY, HA1 B, 902, ILE, O 3.02Å
A, 906, VAL, HA B, 905, GLY, O 3.35Å