Thrombospondin type-1 domain-containing protein 7A

UniProt data

UniProt name: THS7A_HUMAN (Q9UPZ6)

Gene name: THSD7A; Synonyms=KIAA0960

Organism: Homo sapiens (Human).

Function: The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism. {ECO:0000269|PubMed:22194972}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:22194972}; Single-pass type I membrane protein {ECO:0000269|PubMed:22194972}. Secreted {ECO:0000269|PubMed:22194972}.

Transmembrane domains:

  1. 1608-1628, 21 AA, Helical. {ECO:0000255}.

Sequence: 1657 AA

10 20 30 40 50 60 MGLQARRWAS GSRGAAGPRR GVLQLLPLPL PLPLLLLLLL RPGAGRAAAQ GEAEAPTLYL 70 80 90 100 110 120 WKTGPWGRCM GDECGPGGIQ TRAVWCAHVE GWTTLHTNCK QAERPNNQQN CFKVCDWHKE 130 140 150 160 170 180 LYDWRLGPWN QCQPVISKSL EKPLECIKGE EGIQVREIAC IQKDKDIPAE DIICEYFEPK 190 200 210 220 230 240 PLLEQACLIP CQQDCIVSEF SAWSECSKTC GSGLQHRTRH VVAPPQFGGS GCPNLTEFQV 250 260 270 280 290 300 CQSSPCEAEE LRYSLHVGPW STCSMPHSRQ VRQARRRGKN KEREKDRSKG VKDPEARELI 310 320 330 340 350 360 KKKRNRNRQN RQENKYWDIQ IGYQTREVMC INKTGKAADL SFCQQEKLPM TFQSCVITKE 370 380 390 400 410 420 CQVSEWSEWS PCSKTCHDMV SPAGTRVRTR TIRQFPIGSE KECPEFEEKE PCLSQGDGVV 430 440 450 460 470 480 PCATYGWRTT EWTECRVDPL LSQQDKRRGN QTALCGGGIQ TREVYCVQAN ENLLSQLSTH 490 500 510 520 530 540 KNKEASKPMD LKLCTGPIPN TTQLCHIPCP TECEVSPWSA WGPCTYENCN DQQGKKGFKL 550 560 570 580 590 600 RKRRITNEPT GGSGVTGNCP HLLEAIPCEE PACYDWKAVR LGNCEPDNGK ECGPGTQVQE 610 620 630 640 650 660 VVCINSDGEE VDRQLCRDAI FPIPVACDAP CPKDCVLSTW STWSSCSHTC SGKTTEGKQI 670 680 690 700 710 720 RARSILAYAG EEGGIRCPNS SALQEVRSCN EHPCTVYHWQ TGPWGQCIED TSVSSFNTTT 730 740 750 760 770 780 TWNGEASCSV GMQTRKVICV RVNVGQVGPK KCPESLRPET VRPCLLPCKK DCIVTPYSDW 790 800 810 820 830 840 TSCPSSCKEG DSSIRKQSRH RVIIQLPANG GRDCTDPLYE EKACEAPQAC QSYRWKTHKW 850 860 870 880 890 900 RRCQLVPWSV QQDSPGAQEG CGPGRQARAI TCRKQDGGQA GIHECLQYAG PVPALTQACQ 910 920 930 940 950 960 IPCQDDCQLT SWSKFSSCNG DCGAVRTRKR TLVGKSKKKE KCKNSHLYPL IETQYCPCDK 970 980 990 1000 1010 1020 YNAQPVGNWS DCILPEGKVE VLLGMKVQGD IKECGQGYRY QAMACYDQNG RLVETSRCNS 1030 1040 1050 1060 1070 1080 HGYIEEACII PCPSDCKLSE WSNWSRCSKS CGSGVKVRSK WLREKPYNGG RPCPKLDHVN 1090 1100 1110 1120 1130 1140 QAQVYEVVPC HSDCNQYLWV TEPWSICKVT FVNMRENCGE GVQTRKVRCM QNTADGPSEH 1150 1160 1170 1180 1190 1200 VEDYLCDPEE MPLGSRVCKL PCPEDCVISE WGPWTQCVLP CNQSSFRQRS ADPIRQPADE 1210 1220 1230 1240 1250 1260 GRSCPNAVEK EPCNLNKNCY HYDYNVTDWS TCQLSEKAVC GNGIKTRMLD CVRSDGKSVD 1270 1280 1290 1300 1310 1320 LKYCEALGLE KNWQMNTSCM VECPVNCQLS DWSPWSECSQ TCGLTGKMIR RRTVTQPFQG 1330 1340 1350 1360 1370 1380 DGRPCPSLMD QSKPCPVKPC YRWQYGQWSP CQVQEAQCGE GTRTRNISCV VSDGSADDFS 1390 1400 1410 1420 1430 1440 KVVDEEFCAD IELIIDGNKN MVLEESCSQP CPGDCYLKDW SSWSLCQLTC VNGEDLGFGG 1450 1460 1470 1480 1490 1500 IQVRSRPVII QELENQHLCP EQMLETKSCY DGQCYEYKWM ASAWKGSSRT VWCQRSDGIN 1510 1520 1530 1540 1550 1560 VTGGCLVMSQ PDADRSCNPP CSQPHSYCSE TKTCHCEEGY TEVMSSNSTL EQCTLIPVVV 1570 1580 1590 1600 1610 1620 LPTMEDKRGD VKTSRAVHPT QPSSNPAGRG RTWFLQPFGP DGRLKTWVYG VAAGAFVLLI 1630 1640 1650 FIVSMIYLAC KKPKKPQRRQ NNRLKPLTLA YDGDADM

CATM prediction

The sequence of THS7A_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       1610      1620      16
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 KTWVYGVAAGAFVLLIFIVSMIYLACK 7.4 -42.0° 2.9 50.0 -10.3
Model 2 KTWVYGVAAGAFVLLIFIVSMIYLACK 6.7 -55.3° 2.4 47.7 -0.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session