Protein turtle homolog B

UniProt data

UniProt name: TUTLB_HUMAN (Q9UPX0)

Gene name: IGSF9B; Synonyms=KIAA1030

Organism: Homo sapiens (Human).

Function: Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion. {ECO:0000250|UniProtKB:D3ZB51, ECO:0000250|UniProtKB:E9PZ19}.

Subcellular location: Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:D3ZB51}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:D3ZB51}.

Transmembrane domains:

  1. 723-743, 21 AA, Helical. {ECO:0000255}.

Sequence: 1349 AA

10 20 30 40 50 60 MIWYVATFIA SVIGTRGLAA EGAHGLREEP EFVTARAGES VVLRCDVIHP VTGQPPPYVV 70 80 90 100 110 120 EWFKFGVPIP IFIKFGYYPP HVDPEYAGRA SLHDKASLRL EQVRSEDQGW YECKVLMLDQ 130 140 150 160 170 180 QYDTFHNGSW VHLTINAPPT FTETPPQYIE AKEGGSITMT CTAFGNPKPI VTWLKEGTLL 190 200 210 220 230 240 GASGKYQVSD GSLTVTSVSR EDRGAYTCRA YSIQGEAVHT THLLVQGPPF IVSPPENITV 250 260 270 280 290 300 NISQDALLTC RAEAYPGNLT YTWYWQDENV YFQNDLKLRV RILIDGTLII FRVKPEDSGK 310 320 330 340 350 360 YTCVPSNSLG RSPSASAYLT VQYPARVLNM PPVIYVPVGI HGYIRCPVDA EPPATVVKWN 370 380 390 400 410 420 KDGRPLQVEK NLGWTLMEDG SIRIEEATEE ALGTYTCVPY NTLGTMGQSA PARLVLKDPP 430 440 450 460 470 480 YFTVLPGWEY RQEAGRELLI PCAAAGDPFP VITWRKVGKP SRSKHSALPS GSLQFRALSK 490 500 510 520 530 540 EDHGEWECVA TNVVTSITAS THLTVIGTSP HAPGSVRVQV SMTTANVSWE PGYDGGYEQT 550 560 570 580 590 600 FSVWMKRAQF GPHDWLSLPV PPGPSWLLVD TLEPETAYQF SVLAQNKLGT SAFSEVVTVN 610 620 630 640 650 660 TLAFPITTPE PLVLVTPPRC LIANRTQQGV LLSWLPPANH SFPIDRYIME FRVAERWELL 670 680 690 700 710 720 DDGIPGTEGE FFAKDLSQDT WYEFRVLAVM QDLISEPSNI AGVSSTDIFP QPDLTEDGLA 730 740 750 760 770 780 RPVLAGIVAT ICFLAAAILF STLAACFVNK QRKRKLKRKK DPPLSITHCR KSLESPLSSG 790 800 810 820 830 840 KVSPESIRTL RAPSESSDDQ GQPAAKRMLS PTREKELSLY KKTKRAISSK KYSVAKAEAE 850 860 870 880 890 900 AEATTPIELI SRGPDGRFVM DPAEMEPSLK SRRIEGFPFA EETDMYPEFR QSDEENEDPL 910 920 930 940 950 960 VPTSVAALKS QLTPLSSSQE SYLPPPAYSP RFQPRGLEGP GGLEGRLQAT GQARPPAPRP 970 980 990 1000 1010 1020 FHHGQYYGYL SSSSPGEVEP PPFYVPEVGS PLSSVMSSPP LPTEGPFGHP TIPEENGENA 1030 1040 1050 1060 1070 1080 SNSTLPLTQT PTGGRSPEPW GRPEFPFGGL ETPAMMFPHQ LPPCDVPESL QPKAGLPRGL 1090 1100 1110 1120 1130 1140 PPTSLQVPAA YPGILSLEAP KGWAGKSPGR GPVPAPPAAK WQDRPMQPLV SQGQLRHTSQ 1150 1160 1170 1180 1190 1200 GMGIPVLPYP EPAEPGAHGG PSTFGLDTRW YEPQPRPRPS PRQARRAEPS LHQVVLQPSR 1210 1220 1230 1240 1250 1260 LSPLTQSPLS SRTGSPELAA RARPRPGLLQ QAEMSEITLQ PPAAVSFSRK STPSTGSPSQ 1270 1280 1290 1300 1310 1320 SSRSGSPSYR PAMGFTTLAT GYPSPPPGPA PAGPGDSLDV FGQTPSPRRT GEELLRPETP 1330 1340 PPTLPTSGKL QRDRPAPATS PPERALSKL

CATM prediction

The sequence of TUTLB_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  720       730       740    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ARAVLAGIVATICFLAAAILFSTLAAC 7.2 -51.1° 3.3 48.0 -13.1
Prolines* ARPVLAGIVATICFLAAAILFSTLAAC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 726, GLY, HA1 A, 723, VAL, O 3.25Å
B, 727, ILE, HA A, 730, THR, OG1 2.83Å
A, 726, GLY, HA1 B, 723, VAL, O 3.25Å
A, 727, ILE, HA B, 730, THR, OG1 2.83Å