Endothelial protein C receptor

UniProt data

UniProt name: EPCR_HUMAN (Q9UNN8)

Gene name: PROCR; Synonyms=EPCR

Organism: Homo sapiens (Human).

Function: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 211-231, 21 AA, Helical. {ECO:0000255}.

Sequence: 238 AA

10 20 30 40 50 60 MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL GGHLTHVLEG 70 80 90 100 110 120 PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV HQERTLAFPL TIRCFLGCEL 130 140 150 160 170 180 PPEGSRAHVF FEVAVNGSSF VSFRPERALW QADTQVTSGV VTFTLQQLNA YNRTRYELRE 190 200 210 220 230 FLEDTCVQYV QKHISAENTK GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC

CATM prediction

The sequence of EPCR_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    210       220       230  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 YTSLVLGVLVGSFIIAGVAVGIFLCTG 6.3 -47.1° 4.8 56.1 -37.7
Model 2 YTSLVLGVLVGSFIIAGVAVGIFLCTG 7.0 -27.0° 4.2 52.0 -23.7
Model 3 YTSLVLGVLVGSFIIAGVAVGIFLCTG 6.9 -46.0° 2.7 47.2 -21.0
Model 4 YTSLVLGVLVGSFIIAGVAVGIFLCTG 7.2 -48.7° 1.9 44.6 -18.8
Model 5 YTSLVLGVLVGSFIIAGVAVGIFLCTG 7.1 -54.2° 3.6 49.0 -14.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 224, GLY, HA1 A, 221, ILE, O 2.96Å
B, 225, VAL, HA A, 224, GLY, O 2.30Å
B, 228, GLY, HA1 A, 225, VAL, O 2.90Å
A, 224, GLY, HA1 B, 221, ILE, O 2.96Å
A, 225, VAL, HA B, 224, GLY, O 2.30Å
A, 228, GLY, HA1 B, 225, VAL, O 2.90Å