Bcl-2-related ovarian killer protein {ECO:0000303|PubMed:11034351}

UniProt data

UniProt name: BOK_HUMAN (Q9UMX3)

Gene name: BOK {ECO:0000312|HGNC:HGNC:1087}; Synonyms=BCL2L9

Organism: Homo sapiens (Human).

Function: Isoform 2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway. {ECO:0000269|PubMed:15775999}.

Subcellular location: Isoform 2: Membrane {ECO:0000269|PubMed:19942931}. Cytoplasm {ECO:0000269|PubMed:19942931}.

Transmembrane domains:

  1. 189-209, 21 AA, Helical. {ECO:0000255}.

Sequence: 212 AA

10 20 30 40 50 60 MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP 70 80 90 100 110 120 GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAGITW 130 140 150 160 170 180 GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV DCLGEFVRKT LATWLRRRGG WTDVLKCVVS 190 200 210 TDPGLRSHWL VAALCSFGRF LKAAFFVLLP ER

CATM prediction

The sequence of BOK_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      190       200       210
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 RSHWLVAALCSFGRFLKAAFFVLLAER 7.1 -51.0° 1.2 44.8 -9.3
Prolines* RSHWLVAALCSFGRFLKAAFFVLLPER          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 198, GLY, HA1 A, 195, CYS, O 3.09Å
B, 199, ARG, HA A, 198, GLY, O 3.34Å
A, 198, GLY, HA1 B, 195, CYS, O 3.09Å
A, 199, ARG, HA B, 198, GLY, O 3.33Å