Intercellular adhesion molecule 5

UniProt data

UniProt name: ICAM5_HUMAN (Q9UMF0)

Gene name: ICAM5; Synonyms=TLCN, TLN

Organism: Homo sapiens (Human).

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 836-856, 21 AA, Helical. {ECO:0000255}.

Sequence: 924 AA

10 20 30 40 50 60 MPGPSPGLRR ALLGLWAALG LGLFGLSAVS QEPFWADLQP RVAFVERGGS LWLNCSTNCP 70 80 90 100 110 120 RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF FRCARRTLQA RGLIRTFQRP 130 140 150 160 170 180 DRVELMPLPP WQPVGENFTL SCRVPGAGPR ASLTLTLLRG AQELIRRSFA GEPPRARGAV 190 200 210 220 230 240 LTATVLARRE DHGANFSCRA ELDLRPHGLG LFENSSAPRE LRTFSLSPDA PRLAAPRLLE 250 260 270 280 290 300 VGSERPVSCT LDGLFPASEA RVYLALGDQN LSPDVTLEGD AFVATATATA SAEQEGARQL 310 320 330 340 350 360 VCNVTLGGEN RETRENVTIY SFPAPLLTLS EPSVSEGQMV TVTCAAGAQA LVTLEGVPAA 370 380 390 400 410 420 VPGQPAQLQL NATENDDRRS FFCDATLDVD GETLIKNRSA ELRVLYAPRL DDSDCPRSWT 430 440 450 460 470 480 WPEGPEQTLR CEARGNPEPS VHCARSDGGA VLALGLLGPV TRALSGTYRC KAANDQGEAV 490 500 510 520 530 540 KDVTLTVEYA PALDSVGCPE RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLL 550 560 570 580 590 600 RVAREHAGTY RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG 610 620 630 640 650 660 KPQPSVKCVG SGGATEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNR HGSVAKTVVV 670 680 690 700 710 720 SAESPPEMDE STCPSHQTWL EGAEASALAC AARGRPSPGV RCSREGIPWP EQQRVSREDA 730 740 750 760 770 780 GTYHCVATNA HGTDSRTVTV GVEYRPVVAE LAASPPGGVR PGGNFTLTCR AEAWPPAQIS 790 800 810 820 830 840 WRAPPGALNI GLSSNNSTLS VAGAMGSHGG EYECAATNAH GRHARRITVR VAGPWLWVAV 850 860 870 880 890 900 GGAAGGAALL AAGAGLAFYV QSTACKKGEY NVQEAESSGE AVCLNGAGGG AGGAAGAEGG 910 920 PEAAGGAAES PAEGEVFAIQ LTSA

CATM prediction

The sequence of ICAM5_HUMAN returned 8 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         840       850       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 GAWLWVAVGGAAGGAALLAAGAGLAFY 6.4 -51.6° 5.2 40.0 -27.8
Model 2 GAWLWVAVGGAAGGAALLAAGAGLAFY 7.1 -37.0° 2.2 36.1 -26.5
Model 3 GAWLWVAVGGAAGGAALLAAGAGLAFY 6.6 -47.8° -0.0 38.1 -24.1
Model 4 GAWLWVAVGGAAGGAALLAAGAGLAFY 6.8 -55.1° 0.9 49.8 -21.5
Model 5 GAWLWVAVGGAAGGAALLAAGAGLAFY 7.0 -55.0° 2.4 48.1 -20.1
Model 6 GAWLWVAVGGAAGGAALLAAGAGLAFY 7.4 -47.2° 2.3 44.7 -15.1
Model 7 GAWLWVAVGGAAGGAALLAAGAGLAFY 7.3 -54.0° 3.6 35.4 -14.7
Model 8 GAWLWVAVGGAAGGAALLAAGAGLAFY 7.0 -42.2° 1.9 33.3 -5.4
Prolines* GPWLWVAVGGAAGGAALLAAGAGLAFY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 841, GLY, HA1 A, 838, VAL, O 3.08Å
B, 842, GLY, HA2 A, 841, GLY, O 2.33Å
B, 845, GLY, HA1 A, 842, GLY, O 2.78Å
A, 841, GLY, HA1 B, 838, VAL, O 3.08Å
A, 842, GLY, HA2 B, 841, GLY, O 2.33Å
A, 845, GLY, HA1 B, 842, GLY, O 2.78Å