Collagen alpha-1(XVII) chain

UniProt data

UniProt name: COHA1_HUMAN (Q9UMD9)

Gene name: COL17A1; Synonyms=BP180, BPAG2

Organism: Homo sapiens (Human).

Function: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.

Subcellular location: 97 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Localized in the lamina lucida beneath the hemidesmosomes.

Transmembrane domains:

  1. 468-488, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 1497 AA

10 20 30 40 50 60 MDVTKKNKRD GTEVTERIVT ETVTTRLTSL PPKGGTSNGY AKTASLGGGS RLEKQSLTHG 70 80 90 100 110 120 SSGYINSTGS TRGHASTSSY RRAHSPASTL PNSPGSTFER KTHVTRHAYE GSSSGNSSPE 130 140 150 160 170 180 YPRKEFASSS TRGRSQTRES EIRVRLQSAS PSTRWTELDD VKRLLKGSRS ASVSPTRNSS 190 200 210 220 230 240 NTLPIPKKGT VETKIVTASS QSVSGTYDAT ILDANLPSHV WSSTLPAGSS MGTYHNNMTT 250 260 270 280 290 300 QSSSLLNTNA YSAGSVFGVP NNMASCSPTL HPGLSTSSSV FGMQNNLAPS LTTLSHGTTT 310 320 330 340 350 360 TSTAYGVKKN MPQSPAAVNT GVSTSAACTT SVQSDDLLHK DCKFLILEKD NTPAKKEMEL 370 380 390 400 410 420 LIMTKDSGKV FTASPASIAA TSFSEDTLKK EKQAAYNADS GLKAEANGDL KTVSTKGKTT 430 440 450 460 470 480 TADIHSYGSS GGGGSGGGGG VGGAGGGPWG PAPAWCPCGS CCSWWKWLLG LLLTWLLLLG 490 500 510 520 530 540 LLFGLIALAE EVRKLKARVD ELERIRRSIL PYGDSMDRIE KDRLQGMAPA AGADLDKIGL 550 560 570 580 590 600 HSDSQEELWM FVRKKLMMEQ ENGNLRGSPG PKGDMGSPGP KGDRGFPGTP GIPGPLGHPG 610 620 630 640 650 660 PQGPKGQKGS VGDPGMEGPM GQRGREGPMG PRGEAGPPGS GEKGERGAAG EPGPHGPPGV 670 680 690 700 710 720 PGSVGPKGSS GSPGPQGPPG PVGLQGLRGE VGLPGVKGDK GPMGPPGPKG DQGEKGPRGL 730 740 750 760 770 780 TGEPGMRGLP GAVGEPGAKG AMGPAGPDGH QGPRGEQGLT GMPGIRGPPG PSGDPGKPGL 790 800 810 820 830 840 TGPQGPQGLP GTPGRPGIKG EPGAPGKIVT SEGSSMLTVP GPPGPPGAMG PPGPPGAPGP 850 860 870 880 890 900 AGPAGLPGHQ EVLNLQGPPG PPGPRGPPGP SIPGPPGPRG PPGEGLPGPP GPPGSFLSNS 910 920 930 940 950 960 ETFLSGPPGP PGPPGPKGDQ GPPGPRGHQG EQGLPGFSTS GSSSFGLNLQ GPPGPPGPQG 970 980 990 1000 1010 1020 PKGDKGDPGV PGALGIPSGP SEGGSSSTMY VSGPPGPPGP PGPPGSISSS GQEIQQYISE 1030 1040 1050 1060 1070 1080 YMQSDSIRSY LSGVQGPPGP PGPPGPVTTI TGETFDYSEL ASHVVSYLRT SGYGVSLFSS 1090 1100 1110 1120 1130 1140 SISSEDILAV LQRDDVRQYL RQYLMGPRGP PGPPGASGDG SLLSLDYAEL SSRILSYMSS 1150 1160 1170 1180 1190 1200 SGISIGLPGP PGPPGLPGTS YEELLSLLRG SEFRGIVGPP GPPGPPGIPG NVWSSISVED 1210 1220 1230 1240 1250 1260 LSSYLHTAGL SFIPGPPGPP GPPGPRGPPG VSGALATYAA ENSDSFRSEL ISYLTSPDVR 1270 1280 1290 1300 1310 1320 SFIVGPPGPP GPQGPPGDSR LLSTDASHSR GSSSSSHSSS VRRGSSYSSS MSTGGGGAGS 1330 1340 1350 1360 1370 1380 LGAGGAFGEA AGDRGPYGTD IGPGGGYGAA AEGGMYAGNG GLLGADFAGD LDYNELAVRV 1390 1400 1410 1420 1430 1440 SESMQRQGLL QGMAYTVQGP PGQPGPQGPP GISKVFSAYS NVTADLMDFF QTYGAIQGPP 1450 1460 1470 1480 1490 GQKGEMGTPG PKGDRGPAGP PGHPGPPGPR GHKGEKGDKG DQVYAGRRRR RSIAVKP

CATM prediction

The sequence of COHA1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       470       480       49
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 WKWLLGLLLTWLLLLGLLFGLIALAEE 7.0 +53.8° 3.3 80.3 -19.2
Model 2 WKWLLGLLLTWLLLLGLLFGLIALAEE 7.4 -40.0° 4.0 38.0 -1.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 481, LEU, HA A, 480, GLY, O 3.37Å
B, 484, GLY, HA1 A, 480, GLY, O 3.34Å
A, 481, LEU, HA B, 480, GLY, O 3.37Å
A, 484, GLY, HA1 B, 480, GLY, O 3.34Å