UniProt data
UniProt name: CAH14_HUMAN (Q9ULX7)
Gene name: CA14; ORFNames=UNQ690/PRO1335
Organism: Homo sapiens (Human).
Function: Reversible hydration of carbon dioxide.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 291-311, 21 AA, Helical. {ECO:0000255}.
Sequence: 337 AA
10 20 30 40 50 60
MLFSALLLEV IWILAADGGQ HWTYEGPHGQ DHWPASYPEC GNNAQSPIDI QTDSVTFDPD
70 80 90 100 110 120
LPALQPHGYD QPGTEPLDLH NNGHTVQLSL PSTLYLGGLP RKYVAAQLHL HWGQKGSPGG
130 140 150 160 170 180
SEHQINSEAT FAELHIVHYD SDSYDSLSEA AERPQGLAVL GILIEVGETK NIAYEHILSH
190 200 210 220 230 240
LHEVRHKDQK TSVPPFNLRE LLPKQLGQYF RYNGSLTTPP CYQSVLWTVF YRRSQISMEQ
250 260 270 280 290 300
LEKLQGTLFS TEEEPSKLLV QNYRALQPLN QRMVFASFIQ AGSSYTTGEM LSLGVGILVG
310 320 330
CLCLLLAVYF IARKIRKKRL ENRKSVVFTS AQATTEA
CATM prediction
The sequence of CAH14_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 290 300 310 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GEMLSLGVGILVGCLCLLLAVYFIARK | 7.2 | -24.0° | 3.3 | 48.9 | -34.4 |
| Model 2 | GEMLSLGVGILVGCLCLLLAVYFIARK | 7.2 | -33.8° | 5.7 | 34.7 | -20.7 |
| Model 3 | GEMLSLGVGILVGCLCLLLAVYFIARK | 7.1 | -42.7° | 3.5 | 49.9 | -15.2 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 293, LEU, HA | A, 292, SER, O | 2.98Å |
| B, 296, GLY, HA1 | A, 293, LEU, O | 3.46Å |
| A, 293, LEU, HA | B, 292, SER, O | 2.98Å |
| A, 296, GLY, HA1 | B, 293, LEU, O | 3.46Å |
