Plexin-B3

UniProt data

UniProt name: PLXB3_HUMAN (Q9ULL4)

Gene name: PLXNB3; Synonyms=KIAA1206, PLXN6

Organism: Homo sapiens (Human).

Function: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}; Single-pass type I membrane protein {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}. Note=Colocalizes with RIT2/RIN at the plasma membrane.

Transmembrane domains:

  1. 1256-1276, 21 AA, Helical. {ECO:0000255}.

Sequence: 1909 AA

10 20 30 40 50 60 MCHAAQETPL LHHFMAPVMA RWPPFGLCLL LLLLSPPPLP LTGAHRFSAP NTTLNHLALA 70 80 90 100 110 120 PGRGTLYVGA VNRLFQLSPE LQLEAVAVTG PVIDSPDCVP FRDPAECPQA QLTDNANQLL 130 140 150 160 170 180 LVSSRAQELV ACGQVRQGVC ETRRLGDVAE VLYQAEDPGD GQFVAANTPG VATVGLVVPL 190 200 210 220 230 240 PGRDLLLVAR GLAGKLSAGV PPLAIRQLAG SQPFSSEGLG RLVVGDFSDY NNSYVGAFAD 250 260 270 280 290 300 ARSAYFVFRR RGARAQAEYR SYVARVCLGD TNLYSYVEVP LACQGQGLIQ AAFLAPGTLL 310 320 330 340 350 360 GVFAAGPRGT QAALCAFPMV ELGASMEQAR RLCYTAGGRG PSGAEEATVE YGVTSRCVTL 370 380 390 400 410 420 PLDSPESYPC GDEHTPSPIA GRQPLEVQPL LKLGQPVSAV AALQADGHMI AFLGDTQGQL 430 440 450 460 470 480 YKVFLHGSQG QVYHSQQVGP PGSAISPDLL LDSSGSHLYV LTAHQVDRIP VAACPQFPDC 490 500 510 520 530 540 ASCLQAQDPL CGWCVLQGRC TRKGQCGRAG QLNQWLWSYE EDSHCLHIQS LLPGHHPRQE 550 560 570 580 590 600 QGQVTLSVPR LPILDADEYF HCAFGDYDSL AHVEGPHVAC VTPPQDQVPL NPPGTDHVTV 610 620 630 640 650 660 PLALMFEDVT VAATNFSFYD CSAVQALEAA APCRACVGSI WRCHWCPQSS HCVYGEHCPE 670 680 690 700 710 720 GERTIYSAQE VDIQVRGPGA CPQVEGLAGP HLVPVGWESH LALRVRNLQH FRGLPASFHC 730 740 750 760 770 780 WLELPGELRG LPATLEETAG DSGLIHCQAH QFYPSMSQRE LPVPIYVTQG EAQRLDNTHA 790 800 810 820 830 840 LYVILYDCAM GHPDCSHCQA ANRSLGCLWC ADGQPACRYG PLCPPGAVEL LCPAPSIDAV 850 860 870 880 890 900 EPLTGPPEGG LALTILGSNL GRAFADVQYA VSVASRPCNP EPSLYRTSAR IVCVTSPAPN 910 920 930 940 950 960 GTTGPVRVAI KSQPPGISSQ HFTYQDPVLL SLSPRWGPQA GGTQLTIRGQ HLQTGGNTSA 970 980 990 1000 1010 1020 FVGGQPCPIL EPVCPEAIVC RTRPQAAPGE AAVLVVFGHA QRTLLASPFR YTANPQLVAA 1030 1040 1050 1060 1070 1080 EPSASFRGGG RLIRVRGTGL DVVQRPLLSV WLEADAEVQA SRAQPQDPQP RRSCGAPAAD 1090 1100 1110 1120 1130 1140 PQACIQLGGG LLQCSTVCSV NSSSLLLCRS PAVPDRAHPQ RVFFTLDNVQ VDFASASGGQ 1150 1160 1170 1180 1190 1200 GFLYQPNPRL APLSREGPAR PYRLKPGHVL DVEGEGLNLG ISKEEVRVHI GRGECLVKTL 1210 1220 1230 1240 1250 1260 TRTHLYCEPP AHAPQPANGS GLPQFVVQMG NVQLALGPVQ YEAEPPLSAF PVEAQAGVGM 1270 1280 1290 1300 1310 1320 GAAVLIAAVL LLTLMYRHKS KQALRDYQKV LVQLESLETG VGDQCRKEFT DLMTEMTDLS 1330 1340 1350 1360 1370 1380 SDLEGSGIPF LDYRTYAERA FFPGHGGCPL QPKPEGPGED GHCATVRQGL TQLSNLLNSK 1390 1400 1410 1420 1430 1440 LFLLTLIHTL EEQPSFSQRD RCHVASLLSL ALHGKLEYLT DIMRTLLGDL AAHYVHRNPK 1450 1460 1470 1480 1490 1500 LMLRRTETMV EKLLTNWLSI CLYAFLREVA GEPLYMLFRA IQYQVDKGPV DAVTGKAKRT 1510 1520 1530 1540 1550 1560 LNDSRLLRED VEFQPLTLMV LVGPGAGGAA GSSEMQRVPA RVLDTDTITQ VKEKVLDQVY 1570 1580 1590 1600 1610 1620 KGTPFSQRPS VHALDLEWRS GLAGHLTLSD EDLTSVTQNH WKRLNTLQHY KVPDGATVGL 1630 1640 1650 1660 1670 1680 VPQLHRGSTI SQSLAQRCPL GENIPTLEDG EEGGVCLWHL VKATEEPEGA KVRCSSLRER 1690 1700 1710 1720 1730 1740 EPARAKAIPE IYLTRLLSMK GTLQKFVDDT FQAILSVNRP IPIAVKYLFD LLDELAEKHG 1750 1760 1770 1780 1790 1800 IEDPGTLHIW KTNSLLLRFW VNALKNPQLI FDVRVSDNVD AILAVIAQTF IDSCTTSEHK 1810 1820 1830 1840 1850 1860 VGRDSPVNKL LYAREIPRYK QMVERYYADI RQSSPASYQE MNSALAELSG NYTSAPHCLE 1870 1880 1890 1900 ALQELYNHIH RYYDQIISAL EEDPVGQKLQ LACRLQQVAA LVENKVTDL

CATM prediction

The sequence of PLXB3_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         1260      1270      
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 EAQAGVGMGAAVLIAAVLLLTLMYRHK 6.9 -28.0° 5.2 47.0 -24.0
Model 2 EAQAGVGMGAAVLIAAVLLLTLMYRHK 6.8 -40.8° 3.5 37.9 -18.7
Model 3 EAQAGVGMGAAVLIAAVLLLTLMYRHK 6.9 -40.0° 4.5 44.0 -5.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
A, 1276, TYR, HH B, 1276, TYR, OH 2.22Å