Protein HEG homolog 1

UniProt data

UniProt name: HEG1_HUMAN (Q9ULI3)

Gene name: HEG1; Synonyms=KIAA1237

Organism: Homo sapiens (Human).

Function: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. {ECO:0000250}.

Subcellular location: Isoform 2: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 1249-1269, 21 AA, Helical. {ECO:0000255}.

Sequence: 1381 AA

10 20 30 40 50 60 MASPRASRWP PPLLLLLLPL LLLPPAAPGT RDPPPSPARR ALSLAPLAGA GLELQLERRP 70 80 90 100 110 120 EREPPPTPPR ERRGPATPGP SYRAPEPGAA TQRGPSGRAP RGGSADAAWK HWPESNTEAH 130 140 150 160 170 180 VENITFYQNQ EDFSTVSSKE GVMVQTSGKS HAASDAPENL TLLAETADAR GRSGSSSRTN 190 200 210 220 230 240 FTILPVGYSL EIATALTSQS GNLASESLHL PSSSSEFDER IAAFQTKSGT ASEMGTERAM 250 260 270 280 290 300 GLSEEWTVHS QEATTSAWSP SFLPALEMGE LTTPSRKRNS SGPDLSWLHF YRTAASSPLL 310 320 330 340 350 360 DLSSSSESTE KLNNSTGLQS SSVSQTKTMH VATVFTDGGP RTLRSLTVSL GPVSKTEGFP 370 380 390 400 410 420 KDSRIATTSS SVLLSPSAVE SRRNSRVTGN PGDEEFIEPS TENEFGLTSL RWQNDSPTFG 430 440 450 460 470 480 EHQLASSSEV QNGSPMSQTE TVSRSVAPMR GGEITAHWLL TNSTTSADVT GSSASYPEGV 490 500 510 520 530 540 NASVLTQFSD STVQSGGSHT ALGDRSYSES SSTSSSESLN SSAPRGERSI AGISYGQVRG 550 560 570 580 590 600 TAIEQRTSSD HTDHTYLSST FTKGERALLS ITDNSSSSDI VESSTSYIKI SNSSHSEYSS 610 620 630 640 650 660 FFHAQTERSN ISSYDGEYAQ PSTESPVLHT SNLPSYTPTI NMPNTSVVLD TDAEFVSDSS 670 680 690 700 710 720 SSSSSSSSSS SSGPPLPLPS VSQSHHLFSS ILPSTRASVH LLKSTSDAST PWSSSPSPLP 730 740 750 760 770 780 VSLTTSTSAP LSVSQTTLPQ SSSTPVLPRA RETPVTSFQT STMTSFMTML HSSQTADLKS 790 800 810 820 830 840 QSTPHQEKVI TESKSPSLVS LPTESTKAVT TNSPLPPSLT ESSTEQTLPA TSTNLAQMSP 850 860 870 880 890 900 TFTTTILKTS QPLMTTPGTL SSTASLVTGP IAVQTTAGKQ LSLTHPEILV PQISTEGGIS 910 920 930 940 950 960 TERNRVIVDA TTGLIPLTSV PTSAKEMTTK LGVTAEYSPA SRSLGTSPSP QTTVVSTAED 970 980 990 1000 1010 1020 LAPKSATFAV QSSTQSPTTV SSSASVNSCA VNPCLHNGEC VADNTSRGYH CRCPPSWQGD 1030 1040 1050 1060 1070 1080 DCSVDVNECL SNPCPSTAMC NNTQGSFICK CPVGYQLEKG ICNLVRTFVT EFKLKRTFLN 1090 1100 1110 1120 1130 1140 TTVEKHSDLQ EVENEITKTL NMCFSALPSY IRSTVHASRE SNAVVISLQT TFSLASNVTL 1150 1160 1170 1180 1190 1200 FDLADRMQKC VNSCKSSAEV CQLLGSQRRI FRAGSLCKRK SPECDKDTSI CTDLDGVALC 1210 1220 1230 1240 1250 1260 QCKSGYFQFN KMDHSCRACE DGYRLENETC MSCPFGLGGL NCGNPYQLIT VVIAAAGGGL 1270 1280 1290 1300 1310 1320 LLILGIALIV TCCRKNKNDI SKLIFKSGDF QMSPYAEYPK NPRSQEWGRE AIEMHENGST 1330 1340 1350 1360 1370 1380 KNLLQMTDVY YSPTSVRNPE LERNGLYPAY TGLPGSRHSC IFPGQYNPSF ISDESRRRDY F

CATM prediction

The sequence of HEG1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      1250      1260      127
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 YQLITVVIAAAGGGLLLILGIALIVTC 6.9 -55.1° 4.2 37.7 -27.2
Model 2 YQLITVVIAAAGGGLLLILGIALIVTC 6.9 -54.2° 2.5 33.1 -7.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1255, ALA, HA A, 1254, ALA, O 2.68Å
B, 1258, GLY, HA1 A, 1255, ALA, O 2.84Å
A, 1255, ALA, HA B, 1254, ALA, O 2.68Å
A, 1258, GLY, HA1 B, 1255, ALA, O 2.84Å