Leucine-rich repeat and fibronectin type-III domain-containing protein 2

UniProt data

UniProt name: LRFN2_HUMAN (Q9ULH4)

Gene name: LRFN2; Synonyms=KIAA1246, SALM1

Organism: Homo sapiens (Human).

Function: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Transmembrane domains:

  1. 535-555, 21 AA, Helical. {ECO:0000255}.

Sequence: 789 AA

10 20 30 40 50 60 METLLGGLLA FGMAFAVVDA CPKYCVCQNL SESLGTLCPS KGLLFVPPDI DRRTVELRLG 70 80 90 100 110 120 GNFIIHISRQ DFANMTGLVD LTLSRNTISH IQPFSFLDLE SLRSLHLDSN RLPSLGEDTL 130 140 150 160 170 180 RGLVNLQHLI VNNNQLGGIA DEAFEDFLLT LEDLDLSYNN LHGLPWDSVR RMVNLHQLSL 190 200 210 220 230 240 DHNLLDHIAE GTFADLQKLA RLDLTSNRLQ KLPPDPIFAR SQASALTATP FAPPLSFSFG 250 260 270 280 290 300 GNPLHCNCEL LWLRRLERDD DLETCGSPGG LKGRYFWHVR EEEFVCEPPL ITQHTHKLLV 310 320 330 340 350 360 LEGQAATLKC KAIGDPSPLI HWVAPDDRLV GNSSRTAVYD NGTLDIFITT SQDSGAFTCI 370 380 390 400 410 420 AANAAGEATA MVEVSIVQLP HLSNSTSRTA PPKSRLSDIT GSSKTSRGGG GSGGGEPPKS 430 440 450 460 470 480 PPERAVLVSE VTTTSALVKW SVSKSAPRVK MYQLQYNCSD DEVLIYRMIP ASNKAFVVNN 490 500 510 520 530 540 LVSGTGYDLC VLAMWDDTAT TLTATNIVGC AQFFTKADYP QCQSMHSQIL GGTMILVIGG 550 560 570 580 590 600 IIVATLLVFI VILMVRYKVC NHEAPSKMAA AVSNVYSQTN GAQPPPPSSA PAGAPPQGPP 610 620 630 640 650 660 KVVVRNELLD FTASLARASD SSSSSSLGSG EAAGLGRAPW RIPPSAPRPK PSLDRLMGAF 670 680 690 700 710 720 ASLDLKSQRK EELLDSRTPA GRGAGTSARG HHSDREPLLG PPAARARSLL PLPLEGKAKR 730 740 750 760 770 780 SHSFDMGDFA AAAAGGVVPG GYSPPRKVSN IWTKRSLSVN GMLLPFEESD LVGARGTFGS SEWVMESTV

CATM prediction

The sequence of LRFN2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          540       550      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GTMILVIGGIIVATLLVFIVILMVRYK 7.3 -47.2° 1.4 44.7 -12.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 537, VAL, HA A, 536, LEU, O 3.48Å
B, 540, GLY, HA1 A, 537, VAL, O 3.05Å
B, 541, ILE, HA A, 540, GLY, O 3.18Å
A, 537, VAL, HA B, 536, LEU, O 3.48Å
A, 540, GLY, HA1 B, 537, VAL, O 3.05Å
A, 541, ILE, HA B, 540, GLY, O 3.18Å