Cell cycle progression protein 1

UniProt data

UniProt name: CCPG1_HUMAN (Q9ULG6)

Gene name: CCPG1; Synonyms=CCP8, CPR8, KIAA1254

Organism: Homo sapiens (Human).

Function: Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation. {ECO:0000250, ECO:0000269|PubMed:9383053}.

Subcellular location: Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 218-238, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 757 AA

10 20 30 40 50 60 MSENSSDSDS SCGWTVISHE GSDIEMLNSV TPTDSCEPAP ECSSLEQEEL QALQIEQGES 70 80 90 100 110 120 SQNGTVLMEE TAYPALEETS STIEAEEQKI PEDSIYIGTA SDDSDIVTLE PPKLEEIGNQ 130 140 150 160 170 180 EVVIVEEAQS SEDFNMGSSS SSQYTFCQPE TVFSSQPSDD ESSSDETSNQ PSPAFRRRRA 190 200 210 220 230 240 RKKTVSASES EDRLVAEQET EPSKELSKRQ FSSGLNKCVI LALVIAISMG FGHFYGTIQI 250 260 270 280 290 300 QKRQQLVRKI HEDELNDMKD YLSQCQQEQE SFIDYKSLKE NLARCWTLTE AEKMSFETQK 310 320 330 340 350 360 TNLATENQYL RVSLEKEEKA LSSLQEELNK LREQIRILED KGTSTELVKE NQKLKQHLEE 370 380 390 400 410 420 EKQKKHSFLS QRETLLTEAK MLKRELERER LVTTALRGEL QQLSGSQLHG KSDSPNVYTE 430 440 450 460 470 480 KKEIAILRER LTELERKLTF EQQRSDLWER LYVEAKDQNG KQGTDGKKKG GRGSHRAKNK 490 500 510 520 530 540 SKETFLGSVK ETFDAMKNST KEFVRHHKEK IKQAKEAVKE NLKKFSDSVK STFRHFKDTT 550 560 570 580 590 600 KNIFDEKGNK RFGATKEAAE KPRTVFSDYL HPQYKAPTEN HHNRGPTMQN DGRKEKPVHF 610 620 630 640 650 660 KEFRKNTNSK KCSPGHDCRE NSHSFRKACS GVFDCAQQES MSLFNTVVNP IRMDEFRQII 670 680 690 700 710 720 QRYMLKELDT FCHWNELDQF INKFFLNGVF IHDQKLFTDF VNDVKDYLRN MKEYEVDNDG 730 740 750 VFEKLDEYIY RHFFGHTFSP PYGPRSVYIK PCHYSSL

CATM prediction

The sequence of CCPG1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       220       230       24
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 LNKCVILALVIAISMGFGHFYGTIQIQ 6.4 -46.8° 2.3 44.9 -32.9
Model 2 LNKCVILALVIAISMGFGHFYGTIQIQ 7.4 -53.9° 3.6 49.2 -4.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 225, ILE, HA A, 228, SER, OG 3.45Å
B, 229, MET, HA A, 228, SER, O 2.75Å
B, 232, GLY, HA1 A, 229, MET, O 2.48Å
B, 233, HSE, HA A, 232, GLY, O 2.91Å
A, 225, ILE, HA B, 228, SER, OG 3.45Å
A, 229, MET, HA B, 228, SER, O 2.75Å
A, 232, GLY, HA1 B, 229, MET, O 2.48Å
A, 233, HSE, HA B, 232, GLY, O 2.91Å