Neurexin-1

UniProt data

UniProt name: NRX1A_HUMAN (Q9ULB1)

Gene name: NRXN1; Synonyms=KIAA0578

Organism: Homo sapiens (Human).

Function: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, synapse {ECO:0000305}. Note=Localized on the pre-synaptic membrane. {ECO:0000250}.

Transmembrane domains:

  1. 1402-1422, 21 AA, Helical. {ECO:0000255}.

Sequence: 1477 AA

10 20 30 40 50 60 MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP 430 440 450 460 470 480 STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD 490 500 510 520 530 540 PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF 550 560 570 580 590 600 FAIEMLDGHL YLLLDMGSGT IKIKALLKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA 610 620 630 640 650 660 PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA 670 680 690 700 710 720 EVQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS 730 740 750 760 770 780 YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV 790 800 810 820 830 840 NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT 850 860 870 880 890 900 RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR 910 920 930 940 950 960 NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG 970 980 990 1000 1010 1020 YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL 1030 1040 1050 1060 1070 1080 DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC 1090 1100 1110 1120 1130 1140 EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP 1150 1160 1170 1180 1190 1200 PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI 1210 1220 1230 1240 1250 1260 EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG RQLTIFNSQA TIIIGGKEQG 1270 1280 1290 1300 1310 1320 QPFQGQLSGL YYNGLKVLNM AAENDANIAI VGNVRLVGEV PSSMTTESTA TAMQSEMSTS 1330 1340 1350 1360 1370 1380 IMETTTTLAT STARRGKPPT KEPISQTTDD ILVASAECPS DDEDIDPCEP SSGGLANPTR 1390 1400 1410 1420 1430 1440 AGGREPYPGS AEVIRESSST TGMVVGIVAA AALCILILLY AMYKYRNRDE GSYHVDESRN 1450 1460 1470 YISNSAQSNG AVVKEKQPSS AKSSNKNKKN KDKEYYV

CATM prediction

The sequence of NRX1A_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   1400      1410      1420  
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 STTGMVVGIVAAAALCILILLYAMYKY 6.4 -46.8° 3.3 53.9 -30.1
Model 2 STTGMVVGIVAAAALCILILLYAMYKY 7.3 -27.0° 6.0 58.0 -24.3
Model 3 STTGMVVGIVAAAALCILILLYAMYKY 7.3 -37.0° 2.2 36.0 -20.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1403, MET, HA A, 1402, GLY, O 2.41Å
B, 1406, GLY, HA1 A, 1403, MET, O 2.62Å
A, 1403, MET, HA B, 1402, GLY, O 2.41Å
A, 1406, GLY, HA1 B, 1403, MET, O 2.62Å