Transmembrane protease serine 11E

UniProt data

UniProt name: TM11E_HUMAN (Q9UL52)

Gene name: TMPRSS11E; Synonyms=DESC1, TMPRSS11E2; ORFNames=UNQ742/PRO1461

Organism: Homo sapiens (Human).

Function: Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. {ECO:0000250|UniProtKB:Q5S248}.

Subcellular location: Transmembrane protease serine 11E catalytic chain: Secreted {ECO:0000250|UniProtKB:Q5S248}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:Q5S248}.

Transmembrane domains:

  1. 20-40, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 423 AA

10 20 30 40 50 60 MMYRPDVVRA RKRVCWEPWV IGLVIFISLI VLAVCIGLTV HYVRYNQKKT YNYYSTLSFT 70 80 90 100 110 120 TDKLYAEFGR EASNNFTEMS QRLESMVKNA FYKSPLREEF VKSQVIKFSQ QKHGVLAHML 130 140 150 160 170 180 LICRFHSTED PETVDKIVQL VLHEKLQDAV GPPKVDPHSV KIKKINKTET DSYLNHCCGT 190 200 210 220 230 240 RRSKTLGQSL RIVGGTEVEE GEWPWQASLQ WDGSHRCGAT LINATWLVSA AHCFTTYKNP 250 260 270 280 290 300 ARWTASFGVT IKPSKMKRGL RRIIVHEKYK HPSHDYDISL AELSSPVPYT NAVHRVCLPD 310 320 330 340 350 360 ASYEFQPGDV MFVTGFGALK NDGYSQNHLR QAQVTLIDAT TCNEPQAYND AITPRMLCAG 370 380 390 400 410 420 SLEGKTDACQ GDSGGPLVSS DARDIWYLAG IVSWGDECAK PNKPGVYTRV TALRDWITSK TGI

CATM prediction

The sequence of TM11E_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     20        30        40  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 EAWVIGLVIFISLIVLAVCIGLTVHYV 7.2 -51.0° 3.3 48.0 -19.9
Model 2 EAWVIGLVIFISLIVLAVCIGLTVHYV 7.3 -51.0° 4.3 40.0 -8.8
Prolines* EPWVIGLVIFISLIVLAVCIGLTVHYV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 34, VAL, HA A, 33, ALA, O 3.14Å
B, 37, GLY, HA1 A, 34, VAL, O 3.20Å
A, 34, VAL, HA B, 33, ALA, O 3.14Å
A, 37, GLY, HA1 B, 34, VAL, O 3.20Å