Integrin alpha-11

UniProt data

UniProt name: ITA11_HUMAN (Q9UKX5)

Gene name: ITGA11; ORFNames=MSTP018

Organism: Homo sapiens (Human).

Function: Integrin alpha-11/beta-1 is a receptor for collagen.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1142-1164, 23 AA, Helical. {ECO:0000255}.

Sequence: 1188 AA

10 20 30 40 50 60 MDLPRGLVVA WALSLWPGFT DTFNMDTRKP RVIPGSRTAF FGYTVQQHDI SGNKWLVVGA 70 80 90 100 110 120 PLETNGYQKT GDVYKCPVIH GNCTKLNLGR VTLSNVSERK DNMRLGLSLA TNPKDNSFLA 130 140 150 160 170 180 CSPLWSHECG SSYYTTGMCS RVNSNFRFSK TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE 190 200 210 220 230 240 VQHFLINILK KFYIGPGQIQ VGVVQYGEDV VHEFHLNDYR SVKDVVEAAS HIEQRGGTET 250 260 270 280 290 300 RTAFGIEFAR SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL 310 320 330 340 350 360 GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF SLEGTNKNET 370 380 390 400 410 420 SFGLEMSQTG FSSHVVEDGV LLGAVGAYDW NGAVLKETSA GKVIPLRESY LKEFPEELKN 430 440 450 460 470 480 HGAYLGYTVT SVVSSRQGRV YVAGAPRFNH TGKVILFTMH NNRSLTIHQA MRGQQIGSYF 490 500 510 520 530 540 GSEITSVDID GDGVTDVLLV GAPMYFNEGR ERGKVYVYEL RQNLFVYNGT LKDSHSYQNA 550 560 570 580 590 600 RFGSSIASVR DLNQDSYNDV VVGAPLEDNH AGAIYIFHGF RGSILKTPKQ RITASELATG 610 620 630 640 650 660 LQYFGCSIHG QLDLNEDGLI DLAVGALGNA VILWSRPVVQ INASLHFEPS KINIFHRDCK 670 680 690 700 710 720 RSGRDATCLA AFLCFTPIFL APHFQTTTVG IRYNATMDER RYTPRAHLDE GGDRFTNRAV 730 740 750 760 770 780 LLSSGQELCE RINFHVLDTA DYVKPVTFSV EYSLEDPDHG PMLDDGWPTT LRVSVPFWNG 790 800 810 820 830 840 CNEDEHCVPD LVLDARSDLP TAMEYCQRVL RKPAQDCSAY TLSFDTTVFI IESTRQRVAV 850 860 870 880 890 900 EATLENRGEN AYSTVLNISQ SANLQFASLI QKEDSDGSIE CVNEERRLQK QVCNVSYPFF 910 920 930 940 950 960 RAKAKVAFRL DFEFSKSIFL HHLEIELAAG SDSNERDSTK EDNVAPLRFH LKYEADVLFT 970 980 990 1000 1010 1020 RSSSLSHYEV KPNSSLERYD GIGPPFSCIF RIQNLGLFPI HGMMMKITIP IATRSGNRLL 1030 1040 1050 1060 1070 1080 KLRDFLTDEA NTSCNIWGNS TEYRPTPVEE DLRRAPQLNH SNSDVVSINC NIRLVPNQEI 1090 1100 1110 1120 1130 1140 NFHLLGNLWL RSLKALKYKS MKIMVNAALQ RQFHSPFIFR EEDPSRQIVF EISKQEDWQV 1150 1160 1170 1180 PIWIIVGSTL GGLLLLALLV LALWKLGFFR SARRRREPGL DPTPKVLE

CATM prediction

The sequence of ITA11_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   1140      1150      1160    
 |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 QVAIWIIVGSTLGGLLLLALLVLALWKLG 6.7 -47.9° -0.0 38.1 -28.7
Model 2 QVAIWIIVGSTLGGLLLLALLVLALWKLG 7.2 -55.1° 2.4 47.7 -11.8
Prolines* QVPIWIIVGSTLGGLLLLALLVLALWKLG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1147, GLY, HA1 A, 1144, ILE, O 3.04Å
B, 1148, SER, HA A, 1147, GLY, O 2.82Å
B, 1151, GLY, HA1 A, 1148, SER, O 3.35Å
A, 1147, GLY, HA1 B, 1144, ILE, O 3.04Å
A, 1148, SER, HA B, 1147, GLY, O 2.82Å
A, 1151, GLY, HA1 B, 1148, SER, O 3.35Å