Long-chain-fatty-acid--CoA ligase 6

UniProt data

UniProt name: ACSL6_HUMAN (Q9UKU0)

Gene name: ACSL6; Synonyms=ACS2, FACL6, KIAA0837, LACS5

Organism: Homo sapiens (Human).

Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.

Subcellular location: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 25-45, 21 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 697 AA

10 20 30 40 50 60 MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ 70 80 90 100 110 120 SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW 130 140 150 160 170 180 LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT 190 200 210 220 230 240 LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK 250 260 270 280 290 300 CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF 310 320 330 340 350 360 LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP 370 380 390 400 410 420 TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI 430 440 450 460 470 480 QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV 490 500 510 520 530 540 GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD 550 560 570 580 590 600 IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI 610 620 630 640 650 660 VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS 670 680 690 DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM

CATM prediction

The sequence of ACSL6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          30        40       
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 FRSLSATTLVSMGALAAILAYWFTHRA 6.9 -47.1° 1.3 45.1 -34.1
Prolines* FRSLSATTLVSMGALAAILAYWFTHRP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 31, VAL, HA A, 30, LEU, O 3.29Å
B, 34, GLY, HA1 A, 31, VAL, O 2.90Å
B, 35, ALA, HA A, 34, GLY, O 3.12Å
A, 31, VAL, HA B, 30, LEU, O 3.29Å
A, 34, GLY, HA1 B, 31, VAL, O 2.90Å
A, 35, ALA, HA B, 34, GLY, O 3.12Å