Disintegrin and metalloproteinase domain-containing protein 28

UniProt data

UniProt name: ADA28_HUMAN (Q9UKQ2)

Gene name: ADAM28; Synonyms=ADAM23, MDCL

Organism: Homo sapiens (Human).

Function: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 666-686, 21 AA, Helical. {ECO:0000255}.

Sequence: 775 AA

10 20 30 40 50 60 MLQGLLPVSL LLSVAVSAIK ELPGVKKYEV VYPIRLHPLH KREAKEPEQQ EQFETELKYK 70 80 90 100 110 120 MTINGKIAVL YLKKNKNLLA PGYTETYYNS TGKEITTSPQ IMDDCYYQGH ILNEKVSDAS 130 140 150 160 170 180 ISTCRGLRGY FSQGDQRYFI EPLSPIHRDG QEHALFKYNP DEKNYDSTCG MDGVLWAHDL 190 200 210 220 230 240 QQNIALPATK LVKLKDRKVQ EHEKYIEYYL VLDNGEFKRY NENQDEIRKR VFEMANYVNM 250 260 270 280 290 300 LYKKLNTHVA LVGMEIWTDK DKIKITPNAS FTLENFSKWR GSVLSRRKRH DIAQLITATE 310 320 330 340 350 360 LAGTTVGLAF MSTMCSPYSV GVVQDHSDNL LRVAGTMAHE MGHNFGMFHD DYSCKCPSTI 370 380 390 400 410 420 CVMDKALSFY IPTDFSSCSR LSYDKFFEDK LSNCLFNAPL PTDIISTPIC GNQLVEMGED 430 440 450 460 470 480 CDCGTSEECT NICCDAKTCK IKATFQCALG ECCEKCQFKK AGMVCRPAKD ECDLPEMCNG 490 500 510 520 530 540 KSGNCPDDRF QVNGFPCHHG KGHCLMGTCP TLQEQCTELW GPGTEVADKS CYNRNEGGSK 550 560 570 580 590 600 YGYCRRVDDT LIPCKANDTM CGKLFCQGGS DNLPWKGRIV TFLTCKTFDP EDTSQEIGMV 610 620 630 640 650 660 ANGTKCGDNK VCINAECVDI EKAYKSTNCS SKCKGHAVCD HELQCQCEEG WIPPDCDDSS 670 680 690 700 710 720 VVFHFSIVVG VLFPMAVIFV VVAMVIRHQS SREKQKKDQR PLSTTGTRPH KQKRKPQMVK 730 740 750 760 770 AVQPQEMSQM KPHVYDLPVE GNEPPASFHK DTNALPPTVF KDNPVSTPKD SNPKA

CATM prediction

The sequence of ADA28_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         670       680       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 FHFSIVVGVLFAMAVIFVVVAMVIRHQ 7.2 -47.0° 1.3 45.1 -14.5
Prolines* FHFSIVVGVLFPMAVIFVVVAMVIRHQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 670, GLY, HA1 A, 667, ILE, O 3.25Å
B, 671, VAL, HA A, 670, GLY, O 3.49Å
A, 670, GLY, HA1 B, 667, ILE, O 3.25Å
A, 671, VAL, HA B, 670, GLY, O 3.49Å