Paired immunoglobulin-like type 2 receptor alpha

UniProt data

UniProt name: PILRA_HUMAN (Q9UKJ1)

Gene name: PILRA

Organism: Homo sapiens (Human).

Function: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:18358807, ECO:0000269|PubMed:21241660}.

Subcellular location: Isoform 4: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 198-218, 21 AA, Helical. {ECO:0000255}.

Sequence: 303 AA

10 20 30 40 50 60 MGRPLLLPLL PLLLPPAFLQ PSGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE 70 80 90 100 110 120 LATAPDVRIS WRRGHFHRQS FYSTRPPSIH KDYVNRLFLN WTEGQKSGFL RISNLQKQDQ 130 140 150 160 170 180 SVYFCRVELD TRSSGRQQWQ SIEGTKLSIT QAVTTTTQRP SSMTTTWRLS STTTTTGLRV 190 200 210 220 230 240 TQGKRRSDSW HISLETAVGV AVAVTVLGIM ILGLICLLRW RRRKGQQRTK ATTPAREPFQ 250 260 270 280 290 300 NTEEPYENIR NEGQNTDPKL NPKDDGIVYA SLALSSSTSP RAPPSHRPLK SPQNETLYSV LKA

CATM prediction

The sequence of PILRA_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       200       210       22
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 ETAVGVAVAVTVLGIMILGLICLLRWR 7.2 -46.0° 2.7 47.0 -7.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session