Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

UniProt data

UniProt name: ENPP5_HUMAN (Q9UJA9)

Gene name: ENPP5 {ECO:0000312|HGNC:HGNC:13717}; ORFNames=UNQ550/PRO1107

Organism: Homo sapiens (Human).

Function: May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity). {ECO:0000250|UniProtKB:P84039}.

Subcellular location: Secreted {ECO:0000305}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 432-452, 21 AA, Helical. {ECO:0000255}.

Sequence: 477 AA

10 20 30 40 50 60 MTSKFLLVSF ILAALSLSTT FSLQPDQQKV LLVSFDGFRW DYLYKVPTPH FHYIMKYGVH 70 80 90 100 110 120 VKQVTNVFIT KTYPNHYTLV TGLFAENHGI VANDMFDPIR NKSFSLDHMN IYDSKFWEEA 130 140 150 160 170 180 TPIWITNQRA GHTSGAAMWP GTDVKIHKRF PTHYMPYNES VSFEDRVAKI IEWFTSKEPI 190 200 210 220 230 240 NLGLLYWEDP DDMGHHLGPD SPLMGPVISD IDKKLGYLIQ MLKKAKLWNT LNLIITSDHG 250 260 270 280 290 300 MTQCSEERLI ELDQYLDKDH YTLIDQSPVA AILPKEGKFD EVYEALTHAH PNLTVYKKED 310 320 330 340 350 360 VPERWHYKYN SRIQPIIAVA DEGWHILQNK SDDFLLGNHG YDNALADMHP IFLAHGPAFR 370 380 390 400 410 420 KNFSKEAMNS TDLYPLLCHL LNITAMPHNG SFWNVQDLLN SAMPRVVPYT QSTILLPGSV 430 440 450 460 470 KPAEYDQEGS YPYFIGVSLG SIIVIVFFVI FIKHLIHSQI PALQDMHAEI AQPLLQA

CATM prediction

The sequence of ENPP5_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   430       440       450   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 GSYAYFIGVSLGSIIVIVFFVIFIKHL 6.5 -48.0° 0.7 54.1 -23.1
Model 2 GSYAYFIGVSLGSIIVIVFFVIFIKHL 6.9 -23.0° 4.2 54.0 -9.5
Model 3 GSYAYFIGVSLGSIIVIVFFVIFIKHL 7.3 -54.6° 2.4 47.8 -2.4
Prolines* GSYPYFIGVSLGSIIVIVFFVIFIKHL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 433, TYR, HA A, 432, ALA, O 3.16Å
B, 436, GLY, HA1 A, 433, TYR, O 2.71Å
B, 437, VAL, HA A, 436, GLY, O 2.72Å
A, 433, TYR, HA B, 432, ALA, O 3.16Å
A, 436, GLY, HA1 B, 433, TYR, O 2.71Å
A, 437, VAL, HA B, 436, GLY, O 2.72Å