Cadherin-22

UniProt data

UniProt name: CAD22_HUMAN (Q9UJ99)

Gene name: CDH22; Synonyms=C20orf25

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 625-645, 21 AA, Helical. {ECO:0000255}.

Sequence: 828 AA

10 20 30 40 50 60 MRPRPEGRGL RAGVALSPAL LLLLLLPPPP TLLGRLWAAG TPSPSAPGAR QDGALGAGRV 70 80 90 100 110 120 KRGWVWNQFF VVEEYTGTEP LYVGKIHSDS DEGDGAIKYT ISGEGAGTIF LIDELTGDIH 130 140 150 160 170 180 AMERLDREQK TFYTLRAQAR DRATNRLLEP ESEFIIKVQD INDSEPRFLH GPYIGSVAEL 190 200 210 220 230 240 SPTGTSVMQV MASDADDPTY GSSARLVYSV LDGEHHFTVD PKTGVIRTAV PDLDRESQER 250 260 270 280 290 300 YEVVIQATDM AGQLGGLSGS TTVTIVVTDV NDNPPRFPQK MYQFSIQESA PIGTAVGRVK 310 320 330 340 350 360 AEDSDVGENT DMTYHLKDES SSGGDVFKVT TDSDTQEAII VVQKRLDFES QPVHTVILEA 370 380 390 400 410 420 LNKFVDPRFA DLGTFRDQAI VRVAVTDVDE PPEFRPPSGL LEVQEDAQVG SLVGVVTARD 430 440 450 460 470 480 PDAANRPVRY AIDRESDLDQ IFDIDADTGA IVTGKGLDRE TAGWHNITVL AMEADNHAQL 490 500 510 520 530 540 SRASLRIRIL DVNDNPPELA TPYEAAVCED AKPGQLIQTI SVVDRDEPQG GHRFYFRLVP 550 560 570 580 590 600 EAPSNPHFSL LDIQDNTAAV HTQHVGFNRQ EQDVFFLPIL VVDSGPPTLS STGTLTIRIC 610 620 630 640 650 660 GCDSSGTIQS CNTTAFVMAA SLSPGALIAL LVCVLILVVL VLLILTLRRH HKSHLSSDED 670 680 690 700 710 720 EDMRDNVIKY NDEGGGEQDT EAYDMSALRS LYDFGELKGG DGGGSAGGGA GGGSGGGAGS 730 740 750 760 770 780 PPQAHLPSER HSLPQGPPSP EPDFSVFRDF ISRKVALADG DLSVPPYDAF QTYAFEGADS 790 800 810 820 PAASLSSLHS GSSGSEQDFA YLSSWGPRFR PLAALYAGHR GDDEAQAS

CATM prediction

The sequence of CAD22_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          630       640      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 LSAGALIALLVCVLILVVLVLLILTLR 7.3 -47.0° 6.0 45.0 -7.6
Prolines* LSPGALIALLVCVLILVVLVLLILTLR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 626, ALA, HA A, 625, GLY, O 3.25Å
A, 626, ALA, HA B, 625, GLY, O 3.25Å