Potassium voltage-gated channel subfamily E regulatory beta subunit 5

UniProt data

UniProt name: KCNE5_HUMAN (Q9UJ90)

Gene name: KCNE5; Synonyms=AMMECR2, KCNE1L {ECO:0000303|PubMed:10493825}

Organism: Homo sapiens (Human).

Function: Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}.

Subcellular location: Membrane {ECO:0000269|PubMed:20533308}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 61-81, 21 AA, Helical. {ECO:0000255}.

Sequence: 142 AA

10 20 30 40 50 60 MNCSESQRLR TLLSRLLLEL HHRGNASGLG AGPRPSMGMG VVPDPFVGRE VTSAKGDDAY 70 80 90 100 110 120 LYILLIMIFY ACLAGGLILA YTRSRKLVEA KDEPSQACAE HEWAPGGALT ADAEAAAGSQ 130 140 AEGRRQLASE GLPALAQGAE RV

CATM prediction

The sequence of KCNE5_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    60        70        80   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 DAYLYILLIMIFYACLAGGLILAYTRS 7.4 -46.0° 2.7 46.7 -13.8
Model 2 DAYLYILLIMIFYACLAGGLILAYTRS 7.2 -54.7° 4.2 38.3 -7.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 73, LEU, HA A, 72, CYS, O 3.43Å
B, 76, GLY, HA1 A, 73, LEU, O 3.40Å
A, 73, LEU, HA B, 72, CYS, O 3.43Å
A, 76, GLY, HA1 B, 73, LEU, O 3.40Å