UniProt data
UniProt name: GGT7_HUMAN (Q9UJ14)
Gene name: GGT7; Synonyms=GGTL3, GGTL5
Organism: Homo sapiens (Human).
Function: Cleaves glutathione conjugates. {ECO:0000250}.
Subcellular location: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Transmembrane domains:
- 107-127, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 662 AA
10 20 30 40 50 60
MAAENEASQE SALGAYSPVD YMSITSFPRL PEDEPAPAAP LRGRKDEDAF LGDPDTDPDS
70 80 90 100 110 120
FLKSARLQRL PSSSSEMGSQ DGSPLRETRK DPFSAAAAEC SCRQDGLTVI VTACLTFATG
130 140 150 160 170 180
VTVALVMQIY FGDPQIFQQG AVVTDAARCT SLGIEVLSKQ GSSVDAAVAA ALCLGIVAPH
190 200 210 220 230 240
SSGLGGGGVM LVHDIRRNES HLIDFRESAP GALREETLQR SWETKPGLLV GVPGMVKGLH
250 260 270 280 290 300
EAHQLYGRLP WSQVLAFAAA VAQDGFNVTH DLARALAEQL PPNMSERFRE TFLPSGRPPL
310 320 330 340 350 360
PGSLLHRPDL AEVLDVLGTS GPAAFYAGGN LTLEMVAEAQ HAGGVITEED FSNYSALVEK
370 380 390 400 410 420
PVCGVYRGHL VLSPPPPHTG PALISALNIL EGFNLTSLVS REQALHWVAE TLKIALALAS
430 440 450 460 470 480
RLGDPVYDST ITESMDDMLS KVEAAYLRGH INDSQAAPAP LLPVYELDGA PTAAQVLIMG
490 500 510 520 530 540
PDDFIVAMVS SLNQPFGSGL ITPSGILLNS QMLDFSWPNR TANHSAPSLE NSVQPGKRPL
550 560 570 580 590 600
SFLLPTVVRP AEGLCGTYLA LGANGAARGL SGLTQVLLNV LTLNRNLSDS LARGRLHPDL
610 620 630 640 650 660
QSNLLQVDSE FTEEEIEFLE ARGHHVEKVD VLSWVHGSRR TNNFIIAVKD PRSPDAAGAT
IL
CATM prediction
The sequence of GGT7_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 110 120 1 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | QDGLTVIVTACLTFATGVTVALVMQIY | 7.2 | -44.0° | 1.8 | 45.2 | -28.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 117, PHE, HA | A, 116, THR, O | 3.38Å |
| B, 120, GLY, HA1 | A, 117, PHE, O | 3.18Å |
| B, 121, VAL, HA | A, 120, GLY, O | 3.44Å |
| A, 117, PHE, HA | B, 116, THR, O | 3.38Å |
| A, 120, GLY, HA1 | B, 117, PHE, O | 3.18Å |
| A, 121, VAL, HA | B, 120, GLY, O | 3.44Å |