Plexin-A1

UniProt data

UniProt name: PLXA1_HUMAN (Q9UIW2)

Gene name: PLXNA1; Synonyms=NOV, PLXN1

Organism: Homo sapiens (Human).

Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 1245-1265, 21 AA, Helical. {ECO:0000255}.

Sequence: 1896 AA

10 20 30 40 50 60 MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG LTHLVVHEQT 70 80 90 100 110 120 GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS VQSCPHGLGS TDNVNKLLLL 130 140 150 160 170 180 DYAANRLLAC GSASQGICQF LRLDDLFKLG EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ 190 200 210 220 230 240 GQAKLFVGTP IDGKSEYFPT LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP 250 260 270 280 290 300 AFDIYYVYSF RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI 310 320 330 340 350 360 GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK PPKESALCLF 370 380 390 400 410 420 TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL QIDDDFCGQD FNQPLGGTVT 430 440 450 460 470 480 IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA GTRSGRIRKI LVDLSNPGGR PALAYESVVA 490 500 510 520 530 540 QEGSPILRDL VLSPNHQYLY AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI 550 560 570 580 590 600 CSRRDACERA DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF 610 620 630 640 650 660 EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK FASVDFVFYN 670 680 690 700 710 720 CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV NVSEDCPQIL PSTQIYVPVG 730 740 750 760 770 780 VVKPITLAAR NLPQPQSGQR GYECLFHIPG SPARVTALRF NSSSLQCQNS SYSYEGNDVS 790 800 810 820 830 840 DLPVNLSVVW NGNFVIDNPQ NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR 850 860 870 880 890 900 HHCAADTPAS WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV 910 920 930 940 950 960 RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA LSPKRFTFVT 970 980 990 1000 1010 1020 PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP CSFSWRNSRE IRCLTPPGQS 1030 1040 1050 1060 1070 1080 PGSAPIIINI NRAQLTNPEV KYNYTEDPTI LRIDPEWSIN SGGTLLTVTG TNLATVREPR 1090 1100 1110 1120 1130 1140 IRAKYGGIER ENGCLVYNDT TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN 1150 1160 1170 1180 1190 1200 STSFLYYPDP VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT 1210 1220 1230 1240 1250 1260 VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG GGGGLLLLVI 1270 1280 1290 1300 1310 1320 VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF AELQTDIHEL TNDLDGAGIP 1330 1340 1350 1360 1370 1380 FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS 1390 1400 1410 1420 1430 1440 FSMRDRGNVA SLIMTALQGE MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM 1450 1460 1470 1480 1490 1500 LTNWFTFLLY KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY 1510 1520 1530 1540 1550 1560 KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK AADMDLEWRQ 1570 1580 1590 1600 1610 1620 GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL VPKQTSAYNI SNSSTFTKSL 1630 1640 1650 1660 1670 1680 SRYESMLRTA SSPDSLRSRT PMITPDLESG TKLWHLVKNH DHLDQREGDR GSKMVSEIYL 1690 1700 1710 1720 1730 1740 TRLLATKGTL QKFVDDLFET IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW 1750 1760 1770 1780 1790 1800 KSNCLPLRFW VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL 1810 1820 1830 1840 1850 1860 LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS ALHEIYSYIT 1870 1880 1890 KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS

CATM prediction

The sequence of PLXA1_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          1250      1260     
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 TLAAIVGIGGGGGLLLLVIVAVLIAYK 7.0 -30.0° 3.5 53.0 -25.1
Model 2 TLAAIVGIGGGGGLLLLVIVAVLIAYK 6.8 -46.0° 4.7 38.0 -19.4
Model 3 TLAAIVGIGGGGGLLLLVIVAVLIAYK 6.6 -55.3° 2.4 48.1 -15.0
Model 4 TLAAIVGIGGGGGLLLLVIVAVLIAYK 6.8 -53.8° 2.6 33.1 -13.4
Model 5 TLAAIVGIGGGGGLLLLVIVAVLIAYK 6.3 -55.3° 0.3 45.0 -10.9
Model 6 TLAAIVGIGGGGGLLLLVIVAVLIAYK 7.1 +52.0° 1.8 1.0 -10.1
Model 7 TLAAIVGIGGGGGLLLLVIVAVLIAYK 6.8 -54.1° 2.5 33.1 -3.5
Prolines* TLPAIVGIGGGGGLLLLVIVAVLIAYK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1248, GLY, HA1 A, 1245, ALA, O 3.30Å
A, 1248, GLY, HA1 B, 1245, ALA, O 3.30Å