Butyrophilin-like protein 2

UniProt data

UniProt name: BTNL2_HUMAN (Q9UIR0)

Gene name: BTNL2

Organism: Homo sapiens (Human).

Function: Negative regulator of T-cell proliferation. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000269|PubMed:15735647}; Single-pass type II membrane protein {ECO:0000269|PubMed:15735647}. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.

Transmembrane domains:

  1. 7-23, 17 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 455 AA

10 20 30 40 50 60 MVDFPGYNLS GAVASFLFIL LTMKQSEDFR VIGPAHPILA GVGEDALLTC QLLPKRTTMH 70 80 90 100 110 120 VEVRWYRSEP STPVFVHRDG VEVTEMQMEE YRGWVEWIEN GIAKGNVALK IHNIQPSDNG 130 140 150 160 170 180 QYWCHFQDGN YCGETSLLLK VAGLGSAPSI HMEGPGESGV QLVCTARGWF PEPQVYWEDI 190 200 210 220 230 240 RGEKLLAVSE HRIQDKDGLF YAEATLVVRN ASAESVSCLV HNPVLTEEKG SVISLPEKLQ 250 260 270 280 290 300 TELASLKVNG PSQPILVRVG EDIQLTCYLS PKANAQSMEV RWDRSHRYPA VHVYMDGDHV 310 320 330 340 350 360 AGEQMAEYRG RTVLVSDAID EGRLTLQILS ARPSDDGQYR CLFEKDDVYQ EASLDLKVVS 370 380 390 400 410 420 LGSSPLITVE GQEDGEMQPM CSSDGWFPQP HVPWRDMEGK TIPSSSQALT QGSHGLFHVQ 430 440 450 TLLRVTNISA VDVTCSISIP FLGEEKIATF SLSGW

CATM prediction

The sequence of BTNL2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20     
 +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 FAGYNLSGAVASFLFILLTMKQS 7.2 -42.8° 3.0 34.7 -0.4
Prolines* FPGYNLSGAVASFLFILLTMKQS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 8, ASN, HA A, 7, TYR, O 3.27Å
B, 11, GLY, HA1 A, 8, ASN, OD1 2.41Å
B, 11, GLY, HA1 A, 8, ASN, O 3.09Å
B, 12, ALA, HA A, 11, GLY, O 3.46Å
B, 15, SER, HG1 A, 12, ALA, O 2.66Å
A, 8, ASN, HA B, 7, TYR, O 3.27Å
A, 11, GLY, HA1 B, 8, ASN, OD1 2.41Å
A, 11, GLY, HA1 B, 8, ASN, O 3.09Å
A, 12, ALA, HA B, 11, GLY, O 3.46Å
A, 15, SER, HG1 B, 12, ALA, O 2.66Å