Tomoregulin-2

UniProt data

UniProt name: TEFF2_HUMAN (Q9UIK5)

Gene name: TMEFF2; Synonyms=HPP1, TENB2, TPEF; ORFNames=UNQ178/PRO204

Organism: Homo sapiens (Human).

Function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. {ECO:0000269|PubMed:10903839, ECO:0000269|PubMed:17942404}.

Subcellular location: Isoform 3: Secreted.

Transmembrane domains:

  1. 321-341, 21 AA, Helical. {ECO:0000255}.

Sequence: 374 AA

10 20 30 40 50 60 MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD 70 80 90 100 110 120 DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA 130 140 150 160 170 180 CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC 190 200 210 220 230 240 VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG 250 260 270 280 290 300 HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC 310 320 330 340 350 360 EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR IHRQKQNTGH 370 YSSDNTTRAS TRLI

CATM prediction

The sequence of TEFF2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    320       330       340  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 QYVLIAAVIGTIQIAVICVVVLCITRK 7.1 -46.2° 4.7 37.8 -11.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 324, ALA, HA A, 323, ALA, O 3.05Å
B, 327, GLY, HA1 A, 324, ALA, O 3.34Å
A, 324, ALA, HA B, 323, ALA, O 3.05Å
A, 327, GLY, HA1 B, 324, ALA, O 3.34Å