NADH-cytochrome b5 reductase 1

UniProt data

UniProt name: NB5R1_HUMAN (Q9UHQ9)

Gene name: CYB5R1; Synonyms=NQO3A2; ORFNames=UNQ3049/PRO9865

Organism: Homo sapiens (Human).

Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 8-28, 21 AA, Helical. {ECO:0000255}.

Sequence: 305 AA

10 20 30 40 50 60 MGIQTSPVLL ASLGVGLVTL LGLAVGSYLV RRSRRPQVTL LDPNEKYLLR LLDKTTVSHN 70 80 90 100 110 120 TKRFRFALPT AHHTLGLPVG KHIYLSTRID GSLVIRPYTP VTSDEDQGYV DLVIKVYLKG 130 140 150 160 170 180 VHPKFPEGGK MSQYLDSLKV GDVVEFRGPS GLLTYTGKGH FNIQPNKKSP PEPRVAKKLG 190 200 210 220 230 240 MIAGGTGITP MLQLIRAILK VPEDPTQCFL LFANQTEKDI ILREDLEELQ ARYPNRFKLW 250 260 270 280 290 300 FTLDHPPKDW AYSKGFVTAD MIREHLPAPG DDVLVLLCGP PPMVQLACHP NLDKLGYSQK MRFTY

CATM prediction

The sequence of NB5R1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       10        20        30
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TSAVLLASLGVGLVTLLGLAVGSYLVR 6.8 -50.8° 1.2 44.8 -26.7
Prolines* TSPVLLASLGVGLVTLLGLAVGSYLVR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 19, THR, HA A, 18, VAL, O 3.33Å
B, 22, GLY, HA1 A, 19, THR, O 2.78Å
B, 23, LEU, HA A, 22, GLY, O 3.00Å
A, 19, THR, HA B, 18, VAL, O 3.33Å
A, 22, GLY, HA1 B, 19, THR, O 2.78Å
A, 23, LEU, HA B, 22, GLY, O 3.00Å